CAREER: Intricate Molecules from Nature as an Avenue for the Development of New Reactions

有了这个职业奖，有机和高分子化学计划是支持化学和生物化学系教授阿尔门扎卡里安在佛罗里达州立大学的研究。 该研究项目旨在开发合成复杂天然产物的新方法。 基于σ迁移重排和烯醇化化学的几种方法构成了该项目的基础。这些包括路易斯酸介导的杂-Cope重排，其将用于组装恶嗪环，用于合成包含立体四元中心的官能化环己烯醇的串联反应，以及立体选择性生成四取代的无环烯醇化物。 该项目将提高化学合成的效率，扩大可用于药物开发和材料科学等领域研究的有机化合物的范围。扎卡里安教授还将发起各种教育计划，旨在提高人们对化学研究对社会的好处的认识。 这些计划包括开发一系列以博物馆为基础的活动，使公众了解最先进的有机化学，并有可能吸引年轻学生从事科学事业。

With this CAREER Award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Armen Zakarian of the Department of Chemistry and Biochemistry at Florida State University. This research project is directed toward the development of new methods for the synthesis of complex natural products. Several methods based on sigmatropic rearrangements and enolization chemistry form the foundation of the project. These include a Lewis-acid mediated hetero-Cope rearrangement that will be used to assemble oxazine rings, a tandem reaction for the synthesis of functionalized cyclohexenols incorporating a stereogenic quaternary center, and the stereoselective generation of tetrasubstituted acyclic enolates. This project, which will improve efficiency of chemical synthesis, will expand the scope of organic compounds available for research in areas such as drug development and materials science. Professor Zakarian will also initiate variety of educational programs designed to increase awareness of the benefits of chemical research to society. These programs include the development of a museum-based series of activities that will expose the general public to state-of-the-art organic chemistry and have the potential to attract young students to careers in science.