Molecular mechanism of dendritic cell semimaturation and role in maintenance of intestinal homeostasis

在以前的工作中，我们描述了一种DC表型，其在DC与B接触时被诱导。并且其可能支持预防肠的炎性病症。本研究的目的是在体外分子和功能水平上表征和定义这种半成熟DC，并定义参与诱导半成熟致耐受性DC的宿主信号传导途径。通过临床前小鼠模型，我们将研究不同的宿主因子（例如IRAK M、IκB κ、CatS等）是否以及如何影响小鼠的免疫功能。可能有助于维持肠道内稳态或减轻炎症性肠病。本研究为肠道细菌是否影响宿主肠道免疫系统，预防或诱发炎症性肠道疾病提供了依据。

In previous work we described a DC phenotype which is induced upon contact of DC to B. vulgatus and which might support the prevention of inflammatory disorders of the intestine. The aim of this study is to characterize and define this semimature DC at the molecular and functional level in vitro and define host signalling pathways that are involved in the induction of semimature tolerogenic DC. By means of preclinical mouse models we will investigate whether and how different host factors (e.g. IRAK M, IκBζ, CatS etc.) may contribute to the maintenance of intestinal homeostasis or attenuate inflammatory bowel disease. The project ought to provide a basis as to whether commensal bacteria may influence the host intestinal immune system and might prevent or induce inflammatory intestinal diseases.