SBIR Phase I: Development of non-toxic antifouling compounds targeting a key G-protein coupled receptor involved in settlement and metamorphosis of barnacles

SBIR 第一阶段：开发针对参与藤壶沉降和变态的关键 G 蛋白偶联受体的无毒防污化合物

• 批准号: 0839550
• 负责人: Steven Jury
• 金额: --
• 依托单位: MariCal, Inc.
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-01-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0839550&HistoricalAwards=false
• 关键词: SBIR; Phase; Development; non; toxic

This Small Business Innovation Research (SBIR) Phase I project develops a novel, non-toxic, antifouling technology for the aquaculture industry. Unlike existing biocidal metal-based coatings, our technology is based on a class of compounds that inhibit the settlement, attachment, and/or metamorphosis of invertebrates on marine surfaces by modulating the activity of a specific nutrient-salinity sensing receptor found in fouling invertebrates. In initial testing, it was demonstrated that a class of compounds called calcimimetics act on these receptors and possess antifouling activity in barnacles in the lab and the field. These data will be refined utilizing a combination of approaches to identify antifoulants suitable for use in the aquaculture industry. Such a non-toxic antifouling system will either replace or dramatically reduce the metal content of current toxic alternatives.The broader impacts of this research are to benefit society by discovering a non-toxic solution to antifouling. This approach, if successful, will reduce the need for metal-based coatings that are toxic to many non-fouling organisms and to allow for increased aquaculture opportunities that are often in economically depressed areas. One of these areas is downeast Maine and as such this research is carried out in collaboration with the University of Maine. This partnership will form the basis for future private-public projects in Maine?s developing aquaculture industries.

这个小型企业创新研究(SBIR)第一阶段项目为水产养殖业开发了一种新型的、无毒的防污技术。与现有的基于金属的杀生涂层不同，我们的技术基于一类化合物，这些化合物通过调节在污垢无脊椎动物中发现的特定营养盐度传感受体的活性来抑制无脊椎动物在海洋表面的定居、附着和/或变态。在最初的测试中，已经证明了一类被称为拟钙剂的化合物作用于这些受体，并在实验室和野外的藤壶中具有防污活性。这些数据将利用确定适合水产养殖业使用的防污剂的组合方法加以提炼。这种无毒的防污系统将取代或大幅减少目前有毒替代品的金属含量。这项研究的更广泛影响是通过发现无毒的防污解决方案来造福社会。这种方法如果成功，将减少对许多非污染生物有毒的金属涂层的需求，并允许增加通常在经济不景气地区的水产养殖机会。其中一个地区是缅因州的Downeast，因此这项研究是与缅因州大学合作进行的。这一伙伴关系将为缅因州S未来发展水产养殖业的公私项目奠定基础。