CAREER: 3-Iminophosphine Palladium Catalysts for Atom-Efficient Syntheses

职业：用于原子效率合成的 3-亚氨基膦钯催化剂

• 批准号: 0841611
• 负责人: Joseph Schmidt
• 金额: $ 57万
• 依托单位: University of Toledo
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-15 至 2015-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0841611&HistoricalAwards=false
• 关键词: CAREER; Iminophosphine; Palladium; Catalysts; Atom

The Inorganic, Bioinorganic, and Organometallic Chemistry Program supports the work of Professor Joseph A. Schmidt of the University of Toledo to examine recently discovered palladium 3-iminophosphine (3IP) catalysts for the synthesis of biologically-important molecules such as indoles, epithilone analogues, and glycosyl ureas via more efficient pathways. These targets have particular relevance for diabetes and cancer treatments. Catalytic coupling reactions will be screened and optimized to determine the breadth of the reactions amenable to catalysis and the hydroamination of phenylacetylene and isoprene have been chosen as model reactions to identify the unique, selective, and highly reactive catalytic mechanism. High school students participating in the American Chemical Society's Project SEED conduct research in Professor Schmidt's laboratory. These and other students are recruited from the Latino Youth Summit (for grades 6-12). Professor Schmidt has also introduced a hands-on laboratory component to the highly successful Saturday Morning Science Program at the University of Toledo. This program invites teachers, parents and students of all ages and backgrounds to participate in chemistry experiments.

无机，生物无机和有机化学计划支持约瑟夫教授的工作。托莱多大学的施密特研究了最近发现的钯3-亚氨基膦（3 IP）催化剂，用于通过更有效的途径合成生物学上重要的分子，如吲哚，上皮酮类似物和糖基脲。 这些目标与糖尿病和癌症治疗特别相关。 催化偶联反应将被筛选和优化，以确定适合催化的反应的广度，并选择苯乙炔和异戊二烯的加氢胺化作为模型反应，以确定独特的，选择性的，和高反应性的催化机理。 参加美国化学学会SEED项目的高中生在施密特教授的实验室里进行研究。 这些学生和其他学生从拉丁美洲青年峰会（6-12年级）招募。 施密特教授还介绍了一个动手实验室组成部分，在托莱多大学非常成功的星期六上午科学计划。 该计划邀请所有年龄和背景的教师，家长和学生参加化学实验。