CAREER: Atom Transfer Radical Addition and Cyclization Reactions in the Presence of Catalytic Amounts of Copper Complexes

职业：催化量铜配合物存在下的原子转移自由基加成和环化反应

• 批准号: 0844131
• 负责人: Tomislav Pintauer
• 金额: $ 55万
• 依托单位: Duquesne University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-15 至 2014-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0844131&HistoricalAwards=false
• 关键词: CAREER; Atom; Transfer; Radical; Addition

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5). In this CAREER project funded by the Inorganic, Bioinorganic, and Organometallic Chemistry Program of the Chemistry Division, Tomislav Pintauer of Duquesne University will carry out research to develop new catalysts for organic transformations involving free radical intermediates. Pintauer will study how to couple metal complexes that are highly active for halogen atom transfer with reducing agents that can regenerate the starting complex. In this manner a single metal complex can potentially catalyze hundreds of thousands of addition or cyclization reactions per use. The educational plan focuses on a few important items including broadening the undergraduate and graduate curriculum at Duquesne University to include information about catalysis science, developing summer minicourses on x-ray crystallography and NMR methods for metal complexes (available to the Pittsburgh higher education community), and mentoring minority high school students.Besides developing new methodologies, the proposed research will transform catalytic atom transfer reactions from ones that generate large amounts of metal waste and impurities into ones that can function effectively at parts per million levels of metal catalysts. Additionally, the proposed research could take its field to the next level of study, where more advanced methods such as chemoselective and stereoselective catalytic atom transfer radical additions and cyclizations could be discovered. This work has the potential for high impact and should provide significant benefits for the medicinal chemistry field and for the pharmaceutical industry.

该奖项是根据2009年美国复苏和再投资法案（公法111-5）资助的。在这个由化学部无机、生物无机和有机金属化学项目资助的CAREER项目中，杜肯大学的Tomislav Pintauer将进行研究，开发涉及自由基中间体的有机转化的新催化剂。Pintauer将研究如何将对卤素原子转移具有高活性的金属配合物与能够再生起始配合物的还原剂偶联。以这种方式，单个金属配合物每次使用可能催化数十万个加成或环化反应。教育计划集中在几个重要项目上，包括扩大杜肯大学的本科和研究生课程，包括有关催化科学的信息，开发关于金属络合物的x射线晶体学和核磁共振方法的夏季迷你课程（匹兹堡高等教育社区可用），以及指导少数民族高中生。除了开发新的方法外，拟议的研究还将把催化原子转移反应从产生大量金属废物和杂质的反应转变为可以在百万分之一的金属催化剂水平下有效发挥作用的反应。此外，所提出的研究可以将其领域带入下一个研究水平，在那里可以发现更先进的方法，如化学选择性和立体选择性催化原子转移自由基加成和环化。这项工作具有潜在的高影响，并将为药物化学领域和制药工业提供重大利益。