CAREER: Atom Transfer Radical Addition and Cyclization Reactions in the Presence of Catalytic Amounts of Copper Complexes

该奖项是根据2009年《美国复苏和再投资法案》(公法111-5)提供资金的。在这个由化学系无机、生物无机和金属有机化学项目资助的职业项目中，Duqune大学的Tomislav Pintauer将开展研究，开发涉及自由基中间体的有机转化的新催化剂。Pintauer将研究如何将对卤素原子转移具有高活性的金属络合物与可以再生起始络合物的还原剂偶联。以这种方式，一种单一的金属络合物可能在每次使用中催化数十万次加成或环化反应。该教育计划集中在几个重要项目上，包括扩大杜奎恩大学的本科生和研究生课程，将催化科学的信息包括在内，开发关于金属络合物的X射线结晶学和核磁共振方法的暑期微型课程(匹兹堡高等教育社区可用)，以及指导少数族裔高中生。除了开发新的方法外，拟议的研究还将把催化原子转移反应从产生大量金属废物和杂质的反应转变为能够在百万分之几的金属催化剂水平上有效发挥作用的反应。此外，拟议的研究可能会将其领域带入下一阶段的研究，在那里可以发现更先进的方法，如化学选择性和立体选择性催化原子转移自由基加成和环化反应。这项工作有可能产生很大的影响，应该会为药物化学领域和制药业带来巨大的好处。

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5). In this CAREER project funded by the Inorganic, Bioinorganic, and Organometallic Chemistry Program of the Chemistry Division, Tomislav Pintauer of Duquesne University will carry out research to develop new catalysts for organic transformations involving free radical intermediates. Pintauer will study how to couple metal complexes that are highly active for halogen atom transfer with reducing agents that can regenerate the starting complex. In this manner a single metal complex can potentially catalyze hundreds of thousands of addition or cyclization reactions per use. The educational plan focuses on a few important items including broadening the undergraduate and graduate curriculum at Duquesne University to include information about catalysis science, developing summer minicourses on x-ray crystallography and NMR methods for metal complexes (available to the Pittsburgh higher education community), and mentoring minority high school students.Besides developing new methodologies, the proposed research will transform catalytic atom transfer reactions from ones that generate large amounts of metal waste and impurities into ones that can function effectively at parts per million levels of metal catalysts. Additionally, the proposed research could take its field to the next level of study, where more advanced methods such as chemoselective and stereoselective catalytic atom transfer radical additions and cyclizations could be discovered. This work has the potential for high impact and should provide significant benefits for the medicinal chemistry field and for the pharmaceutical industry.