Spreading dynamics and force generation in blood platelets (A12)

血小板中的扩散动力学和力的产生 (A12)

• 批准号: 190886903
• 金额: --
• 依托单位: Institut für Röntgenphysik
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2011
• 资助国家: 德国
• 起止时间: 2010-12-31 至 2018-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/190886903?language=en
• 关键词: Spreading; dynamics; force; generation; blood

Blood platelets are the key cellular players in blood clotting. They spread on surfaces and strongly change their shape. Furthermore, they generate forces and transfer them to the environment. The aim of this project is to understand the cytoskeletal mechanisms behind this dynamic adaption to the new function after spreading. We measure the cell morphology as well as the cellular force fields at high spatial and temporal resolution. We use substrates of different stiffness as well as topography and fluid flow to mimic the situation in injured blood vessels.

血小板是凝血过程中的关键细胞因子。它们散布在表面上，强烈地改变了它们的形状。此外，它们会产生力量，并将它们转移到环境中。这个项目的目的是了解这种在传播后对新功能的动态适应背后的细胞骨架机制。我们测量了细胞形态以及高空间和时间分辨率的细胞力场。我们使用不同硬度的基质以及不同的地形和流体流动来模拟损伤血管的情况。