CAREER: Morphogenetic Primitives: Self-Organizing Geometry Based on Morphogenesis and Evolutionary Computing

职业:形态发生原语:基于形态发生和进化计算的自组织几何

基本信息

  • 批准号:
    0845415
  • 负责人:
  • 金额:
    $ 43.61万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Standard Grant
  • 财政年份:
    2009
  • 资助国家:
    美国
  • 起止时间:
    2009-03-01 至 2015-02-28
  • 项目状态:
    已结题

项目摘要

Morphogenetic Primitives: Self-Organizing Geometry Based on Morphogenesis and Evolutionary ComputingDr. David BreenDepartment of Computer ScienceDrexel UniversityIt has been noted that two types of systems exist in the world: 1) systems designed and built by humans to perform a specific job, and 2) biological systems that self-organize to also perform complex tasks without a master plan or overseer directing the actions. The self-organization found in biological systems is a powerful untapped paradigm that, if formulated and exploited, could lead to a superior approach to designing human-made structures. Self-organization algorithms could enable collections of software agents, micro-devices and engineered cells to form into user-defined shapes using only minimal, local information. Developing these algorithms should lead to advances in geometric computer-aided design, tissue engineering, swarm robotics, sensor networks and the custom-design of living cell aggregates.This research project combines and extends concepts from morphogenesis (the cell-level spatial process that produces the structure of an organism), cell aggregation simulation and evolutionary computing in order to produce a new, organic approach to shape generation. Called Morphogenetic Primitives (MPs), this approach captures the fundamental algorithmic constructs of geometric self-organization and harnesses their capabilities within a software framework. MPs are being applied to a number of innovative and important problem-domain areas. The approach creates a new class of self-organizing modeling primitives that may be programmed to ?grow? shapes that meet a specific need while adapting to constraints in the environment. The conceptual framework of MPs is rooted in developmental biology and is based on the multiple biological/physical mechanisms of morphogenesis. Local cell-level interactions aggregate to create high-level shapes and structures. Given the extreme challenges of determining the correct local actions that produce a desired final structure, evolutionary computing techniques are utilized in order to computationally produce the instructions and equations needed for a specific morphogenetic primitive application.
形态发生原语:基于形态发生和进化计算的自组织几何。人们注意到,世界上存在两种类型的系统:1)由人类设计和建造的系统,用于执行特定的工作;2)自组织的生物系统,它也可以在没有总体计划或监督的情况下执行复杂的任务。在生物系统中发现的自组织是一种强大的未被开发的范例,如果被制定和利用,可能会导致设计人造结构的更好方法。自组织算法可以使软件代理、微型设备和工程细胞的集合仅使用最少的本地信息就能形成用户定义的形状。开发这些算法将导致几何计算机辅助设计、组织工程、群体机器人、传感器网络和活细胞聚集体定制设计的进步。这项研究项目结合并扩展了形态发生(产生有机体结构的细胞级空间过程)、细胞聚集模拟和进化计算的概念,以产生一种新的、有机的形状产生方法。这种方法被称为形态发生基元(MPS),它捕获了几何自组织的基本算法结构,并在软件框架内利用了它们的能力。减贫战略正被应用于一些创新和重要的问题领域。该方法创建了一类新的自组织建模原语,这些原语可以被编程为?增长?在适应环境中的约束的同时满足特定需求的形状。MPS的概念框架植根于发育生物学,并基于形态发生的多种生物学/物理机制。局部细胞级别的相互作用聚集在一起以创建高级别的形状和结构。考虑到确定产生所需最终结构的正确局部动作的极端挑战,进化计算技术被用于计算产生特定形态发生原语应用所需的指令和方程。

项目成果

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David Breen其他文献

Mo1383: SEQUENTIAL TESTING FOR HIGH-RISK NASH BY CT1 FROM LIVER<em>MULTISCAN</em> IMPROVES DIAGNOSTIC YIELD COMPARED TO THE USE OF MRE ALONE
  • DOI:
    10.1016/s0016-5085(22)63655-2
  • 发表时间:
    2022-05-01
  • 期刊:
  • 影响因子:
  • 作者:
    Naim Alkhouri;Elizabeth Shumbayawonda;Cayden Beyer;Carlos Duncker;Atsushi Nakajima;David Breen;Daniel J. Cuthbertson;Stephen A. Harrison;Mazen Noureddin
  • 通讯作者:
    Mazen Noureddin
The Evolving Role of the Clinical Nurse Specialist in Interventional Oncology
临床护理专家在介入肿瘤学中不断变化的角色
  • DOI:
    10.1007/s00270-023-03490-2
  • 发表时间:
    2023
  • 期刊:
  • 影响因子:
    2.9
  • 作者:
    V. Halai;D. Maclean;Victoria Smith;Samantha Beverley;B. Maher;B. Stedman;T. Bryant;David Breen;S. Modi
  • 通讯作者:
    S. Modi
Indwelling pleural catheter for malignant pleural effusion: a real-life experience in a tertiary centre with a dedicated pleural service in the Republic of Ireland
  • DOI:
    10.1007/s11845-025-03999-0
  • 发表时间:
    2025-07-15
  • 期刊:
  • 影响因子:
    1.600
  • 作者:
    Lorraine Thong;Mohammed Mitha;Donna Langan;Helen Mulryan;David Breen
  • 通讯作者:
    David Breen
60 Physician led focused neck ultrasound and cervical lymph node sampling: a survey of lung cancer physicians
60 名由医生主导的聚焦颈部超声和颈淋巴结采样:对肺癌医生的一项调查
  • DOI:
    10.1016/j.lungcan.2025.108170
  • 发表时间:
    2025-02-01
  • 期刊:
  • 影响因子:
    4.400
  • 作者:
    Richard Thorley;Catharine Pearce;David Breen;Cyrus Daneshvar;Maged Hassan
  • 通讯作者:
    Maged Hassan
61 Achieving and maintaining competence as a physician in focused neck ultrasound and cervical lymph node sampling
61. 在聚焦颈部超声和颈部淋巴结采样方面作为一名医生实现并保持能力
  • DOI:
    10.1016/j.lungcan.2025.108171
  • 发表时间:
    2025-02-01
  • 期刊:
  • 影响因子:
    4.400
  • 作者:
    Richard Thorley;Catharine Pearce;David Breen;Cyrus Daneshvar;Maged Hassan
  • 通讯作者:
    Maged Hassan

David Breen的其他文献

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{{ truncateString('David Breen', 18)}}的其他基金

A Design Framework for Programmable Manufacturing of Customized Knitted Materials
定制针织材料可编程制造的设计框架
  • 批准号:
    1537720
  • 财政年份:
    2015
  • 资助金额:
    $ 43.61万
  • 项目类别:
    Standard Grant
Interactive, Freeform Editing of Large-Scale, Multiresolution Level Set Models
大规模、多分辨率水平集模型的交互式、自由形式编辑
  • 批准号:
    0702441
  • 财政年份:
    2007
  • 资助金额:
    $ 43.61万
  • 项目类别:
    Standard Grant
SGER: Automated Shape Composition Via Genetic Programming
SGER:通过遗传编程自动组合形状
  • 批准号:
    0636323
  • 财政年份:
    2006
  • 资助金额:
    $ 43.61万
  • 项目类别:
    Standard Grant
Collaborative Research: Interactive Level-Set Modeling for Visualization of Biological Volume Datasets
协作研究:生物体数据集可视化的交互式水平集建模
  • 批准号:
    0421347
  • 财政年份:
    2003
  • 资助金额:
    $ 43.61万
  • 项目类别:
    Continuing Grant
Collaborative Research: Interactive Level-Set Modeling for Visualization of Biological Volume Datasets
协作研究:生物体数据集可视化的交互式水平集建模
  • 批准号:
    0083287
  • 财政年份:
    2000
  • 资助金额:
    $ 43.61万
  • 项目类别:
    Continuing Grant
Multiresolution Visualization Tools for Interactive Analysis of Large-Scale N-Dimensional Datasets
用于大规模 N 维数据集交互式分析的多分辨率可视化工具
  • 批准号:
    9982273
  • 财政年份:
    1999
  • 资助金额:
    $ 43.61万
  • 项目类别:
    Continuing Grant

相似国自然基金

骨形态发生蛋白(Bone Morphogenetic Proteins,BMP)信号在脊髓损伤中枢神经性疼痛中的作用
  • 批准号:
    81070994
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    2010
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    32.0 万元
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    面上项目

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Collaborative Research: Mechanoregulation of Amnion Patterning through Activation of Bone Morphogenetic Protein Signaling
合作研究:通过激活骨形态发生蛋白信号传导对羊膜模式进行机械调节
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    2325361
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    2023
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Interpreting Bone Morphogenetic Protein Gradients in Vertebrate Development
解释脊椎动物发育中的骨形态发生蛋白梯度
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Collaborative Research: Mechanoregulation of Amnion Patterning through Activation of Bone Morphogenetic Protein Signaling
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    2325360
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    2023
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Exploring evolution of multicellularity and ancient molecular mechanisms underlying morphogenetic movement in amoebozoa
探索变形虫形态发生运动的多细胞进化和古老分子机制
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Investigating the kinetics of endothelial Bone Morphogenetic Protein 9 (BMP9) signalling in Pulmonary Arterial Hypertension
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Function and regulatory mechanisms of the Wnt5a-Ror morphogenetic pathway
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Molecular drivers of tissue-specific morphogenetic programs
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