CAREER: Maturation of Cardiovascular Physiology in Embryonic Reptiles

职业：爬行动物胚胎心血管生理学的成熟

• 批准号: 0845741
• 负责人: Brett Goodwin
• 金额: $ 101.56万
• 依托单位: University of North Dakota Main Campus
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2015-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0845741&HistoricalAwards=false
• 关键词: CAREER; Maturation; Cardiovascular; Physiology; Embryonic

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).The cardiovascular system is the first operational organ system in developing vertebrates and proper control of its function, which transports oxygen and nutrients, is absolutely critical for the subsequent normal development of the animal. Any perturbation, whether natural or experimental, of its normal function will negatively impact further development and ultimately embryo survival. This project will entail an extensive investigation of the cardiovascular system during the development of two reptilian vertebrates, American alligators and common snapping turtles. Prior studies have shown that these animals experience alterations in the developmental environment (the nest), resulting in periods of hypoxia (low oxygen levels). This research project will determine the effects of these hypoxic periods on the gene expression, regulation, and function of the cardiovascular system in order to construct a complete picture of the environment-induced changes in embryonic cardiovascular physiology. Given the potential for variation in nest temperature, water content and oxygen content, this study will clarify how environmental stress can alter the embryonic survival of these species as well as other egg-laying vertebrates. During the tenure of this research project several education goals will be achieved. This project will further physiological education on the UND campus through the development of a specialized course in physiology and will have regional impact through the development of the internet based experimental modules in physiology. In addition, Native American students will participate in a summer research experience program.

该奖项是根据2009年美国复苏和再投资法案（公法111-5）资助的。心血管系统是脊椎动物发育过程中第一个运行的器官系统，其输送氧气和营养物质的功能的正确控制对于动物随后的正常发育至关重要。对其正常功能的任何干扰，无论是自然的还是实验的，都会对进一步的发育和最终的胚胎存活产生负面影响。该项目将对两种爬行动物脊椎动物、美洲短吻鳄和鳄龟的发育过程中的心血管系统进行广泛的研究。先前的研究表明，这些动物经历了发育环境（巢穴）的改变，导致缺氧时期（低氧水平）。该研究项目将确定这些缺氧期对心血管系统基因表达、调节和功能的影响，以便全面了解环境引起的胚胎心血管生理学变化。考虑到巢穴温度、水含量和氧气含量可能发生变化，这项研究将阐明环境压力如何改变这些物种以及其他产卵脊椎动物的胚胎存活率。在该研究项目期间，将实现几个教育目标。该项目将通过开发生理学专业课程来进一步推进UND校园的生理学教育，并将通过开发基于互联网的生理学实验模块来产生区域影响。此外，美国原住民学生将参加夏季研究体验项目。