POSTNATAL MATURATION OF CARDIOVASCULAR REGULATORY SYSTEM
POSTNATAL MATURATION OF CARDIOVASCULAR REGULATORY SYSTEM
批准号:
3336295
负责人:
PHYLLIS M GOOTMAN
金额:
$16.45万
依托单位国家:
美国
项目类别:
财政年份:
1978
资助国家:
美国
项目状态:
已结题
起止时间:
1978-08-01 至 1987-07-31
关键词:
afferent nerve apnea atrium autonomic nervous system baroreceptors bioperiodicity blood pressure cardiovascular function catecholamines cerebral ischemia /hypoxia chemoreceptors efferent nerve electrocardiography electrophysiology growth /development heart rate hemorrhage hypercapnia induced hypothermia kidney circulation neural information processing newborn animals pulmonary edema respiratory function respiratory reflex splanchnic nerves sympathetic nervous system thermoreception vasomotion
中文摘要
心血管调节功能的生后发育过程
在小于1天-3个月龄的仔猪中研究了机制,
从调节系统的传出流出的观点来看。 因为
心血管和呼吸系统之间的密切关系
控制系统,发展产后调节的各个方面,
后一种制度也正在研究之中。 三个具体目标正在
追踪:1)交感神经活动(均为传出神经)的年龄相关差异
放电和血浆儿茶酚胺水平),2)特征
心脏自主调节的发展(心脏记录)
迷走神经运动神经元和使用HRP技术定位心脏交感神经
神经节后索马),3)呼吸节律的年龄相关变化
发电机(各种强制输入的影响,例如,肺膨胀,
化学感受器刺激)。 录音将从Althesin获得
麻醉或去大脑未麻醉仔猪:传出神经
交感神经活动(内脏、颈交感、肾),传出
膈神经放电,心脏迷走神经纤维,疑核运动神经元
腹外侧疑核、主动脉压、心电图、局部动脉
血流量(尤其是肾脏、肠系膜)和适当标记
脉搏 老年大鼠海马神经元传入放电改变的年龄效应
各种心血管-呼吸受体,例如心肺,
动脉压力感受器,中枢心血管和呼吸系统
将对控制系统进行评估。 交感神经系统中常见的周期性
与心动周期相关的放电和周期性(由EKG指示)
或中枢呼吸循环(由传出膈神经放电指示)
通过互相关和功率谱分析揭示,
特别是功率谱等效性和相干性的测试。 的
脑刺激和应激(如高碳酸血症、缺氧)的影响
还将评估出血。 结果的依赖性将是
在6个年龄组的仔猪中进行了统计学测定。 结果将
有助于我们理解子宫外的循环调节
环境和我们对监管程度的了解,
新生儿的心血管功能。 信息将
这是必要的理解反射参与
对各种应激(高碳酸血症,出血,
缺氧),特别是与生命中最脆弱的时期有关,
那个孩子
英文摘要
The time course of postnatal development of cardiovascular regulatory
mechanisms is being studied in piglets Less than 1 day-3 months of age,
from the viewpoint of efferent out-flow of the regulatory system. Because
of the close interrelationship between the cardiovascular and respiratory
controlling systems, aspects of developing postnatal regulation of the
latter system are also being studied. Three specific aims are being
pursued: 1) age-related differences in sympathetic activity (both efferent
discharge and plasma catecholamine levels), 2) characteristics of
development of autonomic regulation of the heart (recordings from cardiac
vagal motoneurons and use of HRP techniques to locate cardiac sympathetic
postganglionic soma), 3) age-related changes in the respiratory rhythm
generator (efects of various forcing inputs, e.g., lung inflation,
chemoreceptor stimulation). Recordings will be obtained from Althesin
anesthetized or decerebrate unanesthetized piglets of: efferent
sympathetic activity (splanchnic, cervical sympathetic, renal), efferent
phrenic discharge, cardiac vagal fibers, motoneurons in nucleurs ambiguus
and ventrolateral nucleus ambiguus, aortic pressure, EKG, regional arterial
blood flow (particularly renal, mesenteric) and appropriate marking
pulses. The age-related effects of alterations in afferent discharge from
various cardiovascular-respiratory receptors, e.g. cardiopulmonary,
arterial baroreceptors, on central cardiovascular and respiratory
controlling systems will be evaluated. Common periodicities in sympathetic
discharge and periodicities related to the cardiac cycle (indicated by EKG)
or central respiratory cycle (indicated by efferent phrenic discharge) are
being revealed by cross correlation and power spectral analyses,
particularly tests for power spectral equivalence and coherence. The
effects of brain stimulation and of stresses such as hypercapnia, hypoxia
and hemorrhage will also be evaluated. Age-dependency of results will be
determined statistically in 6 age groups of piglets. The results will
contribute to our understanding of circulatory adjustments to extrauterine
environment and to our knowledge of the degree of regulation of
cardiovascular function available in the neonate. Information will be
obtained which is necessary for the understanding of reflexes involved in
physiological adjustments to various stresses (hypercapnia, hemorrhage,
hypoxia), relevant especially to the most vulnerable period in the life of
the child.
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资助金额:$8.05万
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资助金额:$22.52万
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POSTNATAL MATURATION OF CARDIOVASCULAR REGULATORY SYSTEM
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批准号:2215398
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资助金额:$27.28万
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资助金额:$29.27万
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POSTNATAL MATURATION OF CARDIOVASCULAR REGULATORY SYSTEM
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资助金额:$18.71万
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财政年份:1978
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负责人:PHYLLIS M GOOTMAN
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依托单位:
POSTNATAL MATURATION OF CARDIOVASCULAR REGULATORY SYSTEM
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批准号:3336294
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项目类别:
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资助金额:$0.71万
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负责人:PHYLLIS M GOOTMAN
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依托单位:
POSTNATAL MATURATION OF CARDIOVASCULAR REGULATORY SYSTEM
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批准号:3336296
-
项目类别:
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资助金额:$15.6万
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财政年份:1978
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负责人:PHYLLIS M GOOTMAN
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依托单位:
海外基金