CAREER: Distribution of fitness effects, identity and interaction of beneficial mutations available for adaptation

职业：适应性效应的分布、可用于适应的有益突变的身份和相互作用

• 批准号: 0845893
• 负责人: Christopher Marx
• 金额: $ 70.25万
• 依托单位: Harvard University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2014-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0845893&HistoricalAwards=false
• 关键词: CAREER; Distribution; fitness; effects; identity

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).Population genetics provides powerful, well-tested theory for the fate of existing versions of genes in a population during evolution. In contrast, no strong quantitative framework exists to predict how new versions of genes arise and take over due to natural selection. Questions critical to understanding the basis of adaptation such as how often beneficial mutations occur, the relative balance of small vs. large beneficial mutations, and why adaptation to new environments almost always slows down rapidly with time remain unanswered. This proposal synthesizes recently developed population genetic theory, a novel, newly-developed marker system for tracking subpopulation dynamics, and cutting-edge techniques for high-throughput culturing, whole-genome sequencing, and assaying frequencies of different versions of genes to address a fundamental question - what is the raw material available for adaptation? - in a manner not possible previously.A deeper understanding of adaptation is critical to predict how populations and communities will respond to rapid natural or anthropogenic changes, including climate change, ocean acidification, the harsh environments used in biotechnological processes, or emerging diseases. The research incorporates diverse educational and training activities such as an Evolution in Action undergraduate course, high school outreach laboratories, teacher training, and the development of videos for museum exhibits.

该奖项是根据2009年美国复苏和再投资法案（公法111-5）资助的。人口遗传学为人口中现有基因版本在进化过程中的命运提供了强有力的，经过充分检验的理论。相比之下，没有强有力的定量框架来预测新版本的基因是如何产生的，并由于自然选择而接管。对于理解适应的基础至关重要的问题，例如有益突变发生的频率，小与大有益突变的相对平衡，以及为什么对新环境的适应几乎总是随着时间的推移而迅速减缓，仍然没有答案。该提案综合了最近开发的种群遗传理论，一种新的，新开发的标记系统，用于跟踪亚种群动态，以及高通量培养，全基因组测序和测定不同版本基因频率的尖端技术，以解决一个根本问题-适应的原材料是什么？- 更深入地了解适应对于预测人口和社区将如何应对快速的自然或人为变化至关重要，这些变化包括气候变化，海洋酸化，生物技术过程中使用的恶劣环境或新出现的疾病。该研究结合了多种教育和培训活动，如行动中的演变本科课程，高中外展实验室，教师培训，以及博物馆展览视频的开发。