Comparison of 2 ways exercise-intervention for effects on fat distribution, fractions of free fatty acids and physical fitness

两种运动干预方式对脂肪分布、游离脂肪酸分数和体能影响的比较

• 批准号: 23500854
• 负责人: KAWAI Toshihide
• 金额: $ 3.24万
• 依托单位: Keio University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23500854/
• 关键词: 血中脂肪酸分画; エクササイズ; 体脂肪分布; 遊離脂肪酸分画; 運動処方

We evaluated the relationships between the composition of free fatty acids (FFA) and metabolic parameters, including body fat distribution. The study subjects were 83 Japanese (46 men/37 women) who underwent 75g-OGTT. 24 fractions of serum FFA, lipids, and fat distribution by CT scanning were measured. Our data suggest that linoleic acid level was inversely correlated with accumulation of visceral fat in relation to a reduction of insulin resistance. We evaluated an original treadmill protocol "KEIO-SENIOR" which we developed for patients with diabetes who need exercise prescription. The study subjects were 43 Japanese. Based on our findings, we made an exercise prescription. After 6 months, we found significant weight reduction, decreased blood pressures and improvement of glycemic control. We followed 12 subjects for about 2 years. Our data suggest that the changes in linoleic acid level were inversely correlated with the changes in visceral fat in relation to insulin resistance.

我们评估了游离脂肪酸（FFA）的组成和代谢参数，包括体脂分布之间的关系。研究受试者为83名日本人（46名男性/37名女性），他们接受了75 g-OGTT。测定血清FFA、血脂及CT脂肪分布的24个组分。我们的数据表明，亚油酸水平与内脏脂肪的积累呈负相关，与胰岛素抵抗的减少有关。我们评估了一个原始的跑步机协议“KEIO-SENIOR”，我们开发的糖尿病患者谁需要运动处方。研究对象为43名日本人。根据我们的研究结果，我们制定了一个运动处方。6个月后，我们发现体重显著减轻，血压降低，血糖控制改善。我们对12名受试者进行了为期约2年的随访。我们的数据表明，亚油酸水平的变化与胰岛素抵抗相关的内脏脂肪的变化呈负相关。

项目成果

A treadmill protocol " KEIO-SENIOR " for the elderly to evaluate their physical fitness and make a prescription for exercise

跑步机协议“KEIO-SENIOR”供老年人评估身体健康并制定运动处方

• 发表时间: 2012
• 作者: Kawai T;et al
• 通讯作者: et al

Relationships between changes in composition of major fatty acids and changes in fat distribution, and insulin resistance in Japanese

日本人主要脂肪酸组成的变化和脂肪分布的变化与胰岛素抵抗之间的关系

• 发表时间: 2013
• 作者: Kawai T;et al
• 通讯作者: et al

体脂肪分布、血中脂肪酸分画、経口糖負荷試験(OGTT)時の各指標の経時的変化の関連

口服葡萄糖耐量试验（OGTT）时体脂肪分布、血液脂肪酸分数与各指标随时间变化的关系

• 发表时间: 2013
• 作者: 河合俊英;小熊祐子;勝川史憲;東宏一郎;田中久美子;目黒周;税所芳史;松本秀男;伊藤裕
• 通讯作者: 伊藤裕

中高年肥満者への運動処方作成を目的としたTreadmill protocol「KEIO-SENIOR」とその臨床応用

中老年肥胖者运动处方跑步机协议“KEIO-SENIOR”及其临床应用

• 发表时间: 2012
• 作者: 河合俊英;小熊祐子;勝川史憲;東宏一郎;松本秀男;伊藤 裕;河合俊英ら;河合俊英ら
• 通讯作者: 河合俊英ら

血中脂肪酸分画と体脂肪分布, 経口糖負荷試験(OGTT)時の各指標との関連

口服葡萄糖耐量试验（OGTT）时血脂肪酸分数、体脂肪分布与各项指标的关系

• 发表时间: 2011
• 作者: Kawai T;Oguma Y;Katsukawa F;Azuma K;Tanaka K;Ishida H;Matsumoto H;Itoh H;河合俊英ら
• 通讯作者: 河合俊英ら