Comparison of 2 ways exercise-intervention for effects on fat distribution, fractions of free fatty acids and physical fitness

我们评估了游离脂肪酸(FFA)的组成与代谢参数之间的关系，包括体内脂肪分布。研究对象是83名日本人(46名男性，37名女性)，他们接受了75G-OGTT。测定24组血清游离脂肪酸、血脂及CT扫描脂肪分布。我们的数据表明，亚油酸水平与内脏脂肪的积累呈负相关，而内脏脂肪的积累与胰岛素抵抗的减少有关。我们评估了我们为需要运动处方的糖尿病患者开发的原始跑步机方案“Keio-High”。研究对象为43名日本人。根据我们的发现，我们开了一张运动处方。6个月后，我们发现体重明显减轻，血压下降，血糖控制改善。我们对12名受试者进行了大约2年的跟踪调查。我们的数据表明，亚油酸水平的变化与内脏脂肪的变化呈负相关，与胰岛素抵抗有关。

We evaluated the relationships between the composition of free fatty acids (FFA) and metabolic parameters, including body fat distribution. The study subjects were 83 Japanese (46 men/37 women) who underwent 75g-OGTT. 24 fractions of serum FFA, lipids, and fat distribution by CT scanning were measured. Our data suggest that linoleic acid level was inversely correlated with accumulation of visceral fat in relation to a reduction of insulin resistance. We evaluated an original treadmill protocol "KEIO-SENIOR" which we developed for patients with diabetes who need exercise prescription. The study subjects were 43 Japanese. Based on our findings, we made an exercise prescription. After 6 months, we found significant weight reduction, decreased blood pressures and improvement of glycemic control. We followed 12 subjects for about 2 years. Our data suggest that the changes in linoleic acid level were inversely correlated with the changes in visceral fat in relation to insulin resistance.