CAREER: Bio-Manufacturing Heterogeneous Multi-scale 3D Matrices for Engineering Living Tissue Systems

职业：用于工程活组织系统的生物制造异质多尺度 3D 矩阵

• 批准号: 0846610
• 负责人: Binil Starly
• 金额: $ 40万
• 依托单位: University of Oklahoma Norman Campus
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-02-01 至 2013-10-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0846610&HistoricalAwards=false
• 关键词: CAREER; Bio; Manufacturing; Heterogeneous; Multi

The research objective of this Faculty Early Career Development (CAREER) award is to investigate the process variables that will enable the assembly of multi-scale patterned structures through the hybrid application of nozzle deposition and near field electro-spinning manufacturing processes. These structures will be used to advance our understanding on the influence of spatially patterned structures containing both sub-micron to meso-scale dimensional features on the behavior of living cells. The development of the proposed manufacturing platform will enable the fabrication of complex tissue engineering constructs for engineering living tissue systems. The approach to achieve this objective includes biomaterial synthesis, rheological characterization, process modeling and fabrication of spatially patterned heterogeneous structures for biological testing. The educational objective of this award is to impart a vertical-integration-of-design-and-manufacturing-education based theme at the high school, undergraduate and graduate levels. In doing so, the plan aims to inspire high school students to pursue engineering education, promote the active participation of underrepresented minorities in engineering and to provide graduate students with expertise in bio-manufacturing systems. The approach to achieve these educational objectives includes active participation in the Oklahoma STARBASE organization targeted for K-12 students, the formation of a hovercraft club for freshman engineering students, and by facilitating graduate student international laboratory participation in South Korea.The broader impact of this research lies in the capability to print heterogeneous structures at multiple length scales. Specifically, this plan proposes the next generation of scalable bio-manufacturing systems for the fabrication of polymeric medical implants and in-vitro human tissue analog systems. The investigation into cell-environment interaction will help engineers, biologists and clinicians to better understand the role of engineered constructs for regenerative medicine. The proposed educational activities will enhance design and manufacturing education for undergraduate and graduate students at the University of Oklahoma. The hovercraft club at the university will introduce the art of engineering through a design and manufacturing perspective for students, and also serve as a focal point for attracting high school students to the engineering discipline. This CAREER plan will also help to setup state-of-the-art infrastructure in advanced manufacturing and usher in new multi-disciplinary collaborative activities.

该学院早期职业发展（CAREER）奖的研究目标是调查过程变量，这些变量将通过喷嘴沉积和近场静电纺丝制造工艺的混合应用实现多尺度图案化结构的组装。 这些结构将用于推进我们对包含亚微米到中尺度尺寸特征的空间图案化结构对活细胞行为的影响的理解。拟议的制造平台的发展将使复杂的组织工程结构的工程活组织系统的制造。实现这一目标的方法包括生物材料合成、流变学表征、过程建模和用于生物测试的空间图案化异质结构的制造。该奖项的教育目标是在高中，本科和研究生阶段传授垂直整合的设计和制造教育为基础的主题。在这样做的过程中，该计划旨在鼓励高中生接受工程教育，促进代表性不足的少数群体积极参与工程，并为研究生提供生物制造系统方面的专门知识。实现这些教育目标的方法包括积极参与针对K-12学生的俄克拉荷马州STARBASE组织，为大一工程专业学生成立气垫船俱乐部，以及促进研究生在韩国的国际实验室参与。具体而言，该计划提出了下一代可扩展的生物制造系统，用于制造聚合物医疗植入物和体外人体组织模拟系统。对细胞与环境相互作用的研究将有助于工程师、生物学家和临床医生更好地理解再生医学工程构建体的作用。拟议的教育活动将加强设计和制造教育的本科生和研究生在俄克拉荷马州大学。该大学的气垫船俱乐部将通过设计和制造的角度为学生介绍工程艺术，并作为吸引高中生进入工程学科的焦点。该职业计划还将有助于在先进制造业中建立最先进的基础设施，并引入新的多学科合作活动。