CAREER: Physico-Chemical Modeling of Filopodia Initiation, Dynamics, and Spatio-Temporal Regulation

职业：丝状伪足起始、动力学和时空调节的物理化学模型

• 批准号: 0846701
• 负责人: Garegin Papoian
• 金额: $ 60万
• 依托单位: University of North Carolina at Chapel Hill
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0846701&HistoricalAwards=false
• 关键词: CAREER; Physico; Chemical; Modeling; Filopodia

Garegin Papoian of the University of North Carolina Chapel Hill is supported by a CAREER award from the Theoretical and Computational Chemistry program to carry out research on the development of a physico-chemical modeling technique for filipodia initiation and dynamics. The physical chemistry of these mesoscopic organelles is not well understood. In this research, Papoian and his group are elucidating the mechanism of the temporally-controlled self-assembly of actin-filament bundles that is driven by coupling among spatially-localized mechanical and chemical interactions. Models of filopodia growth-retraction dynamics are being developed which take into account the spatial localization of regulatory proteins.The work is having a broad impact through its connection to basic biological science, but also through several outreach initiatives to high school students and under-represented minorities that Papoian is developing. He is also developing an online CyberBacteria project which will allow young students to experience the excitement of cutting-edge research problems.

北卡罗来纳州查佩尔山大学的Garegin Papoian获得了理论和计算化学项目的职业奖的支持，以开展关于丝状体起始和动力学的物理化学建模技术的发展的研究。这些介观细胞器的物理化学还没有得到很好的理解。 在这项研究中，Papoian和他的团队正在阐明肌动蛋白丝束的时间控制自组装机制，该机制是由空间局部化的机械和化学相互作用之间的耦合驱动的。 正在开发的丝状伪足生长-收缩动力学模型考虑到了调节蛋白的空间定位。这项工作通过其与基础生物科学的联系产生了广泛的影响，但也通过Papoian正在开发的几项针对高中生和代表性不足的少数民族的外展计划产生了广泛的影响。 他还在开发一个在线CyberBacteria项目，让年轻学生体验前沿研究问题的兴奋。