CAREER: New Uses of Pyridine Ring Opening Reactions and Their Products, and Applications to Natural Product Synthesis

为开发天然产物合成的新方法，开发具有百年历史的吡啶的Zincke开环反应是这项赠款支持的研究的重点。具体地说，拟议的研究涉及进一步开发将吡啶转化为其他杂环的方法，以及从吡啶开环产物生成立体定义的双烯和多环内酰胺的方法，称为Zincke醛。这些反应类型中的每一种都适用于天然产物合成中的问题。凭借这一职业奖，有机和高分子化学计划支持加州大学欧文分校化学系教授克里斯托弗·范德沃的研究。Vanderwal教授的研究重点是天然产物的合成和在制药领域应用的新反应发现。范德沃教授还在寻求提高化学专业研究生的非正式和正式沟通技能。该计划的主要内容包括介绍研究生主持的系列研讨会和研究生级别的研讨会课程，在这些课程中，学生相互介绍授课材料。

Exploitation of the century-old Zincke ring-opening reaction of pyridines for the development of new methods for natural product synthesis is the focus of the research supported by this grant. Specifically, the proposed research involves the further development of methods for converting pyridines into other heterocycles and for generating stereodefined dienes and polycyclic lactams from the pyridine-ring-opened products, called Zincke aldehydes. Each of these reaction types is applicable to problems in natural product synthesis.With this CAREER award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Christopher Vanderwal of the Department of Chemistry at the University of California, Irvine. Professor Vanderwal's research focuses on natural product synthesis and new reaction discovery for applications in the pharmaceutical field. Professor Vanderwal is also seeking to improve informal and formal communication skills for graduate students in chemistry. Key aspects of this program include the introduction of a graduate student hosted seminar series and graduate-level seminar courses, wherein the students present the lecture materials to each other.