CAREER: New Uses of Pyridine Ring Opening Reactions and Their Products, and Applications to Natural Product Synthesis

职业：吡啶开环反应及其产物的新用途以及在天然产物合成中的应用

• 批准号: 0847061
• 负责人: Christopher Vanderwal
• 金额: $ 55万
• 依托单位: University of California-Irvine
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-03-01 至 2014-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0847061&HistoricalAwards=false
• 关键词: CAREER; New; Uses; Pyridine; Ring

Exploitation of the century-old Zincke ring-opening reaction of pyridines for the development of new methods for natural product synthesis is the focus of the research supported by this grant. Specifically, the proposed research involves the further development of methods for converting pyridines into other heterocycles and for generating stereodefined dienes and polycyclic lactams from the pyridine-ring-opened products, called Zincke aldehydes. Each of these reaction types is applicable to problems in natural product synthesis.With this CAREER award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Christopher Vanderwal of the Department of Chemistry at the University of California, Irvine. Professor Vanderwal's research focuses on natural product synthesis and new reaction discovery for applications in the pharmaceutical field. Professor Vanderwal is also seeking to improve informal and formal communication skills for graduate students in chemistry. Key aspects of this program include the introduction of a graduate student hosted seminar series and graduate-level seminar courses, wherein the students present the lecture materials to each other.

利用具有百年历史的吡啶类化合物的Zincke开环反应，开发天然产物合成的新方法，是该基金支持的研究重点。具体而言，拟议的研究涉及进一步开发将吡啶转化为其他杂环的方法，以及从吡啶开环产物（称为Zincke醛）生成立体定向二烯和多环内酰胺的方法。这些反应类型中的每一种都适用于天然产物合成中的问题。通过这个CAREER奖，有机和高分子化学计划支持了加州大学欧文分校化学系的Christopher Vanderwal教授的研究。Vanderwal教授的研究重点是天然产物合成和制药领域应用的新反应发现。Vanderwal教授还在寻求提高化学研究生的非正式和正式沟通技巧。该计划的关键方面包括介绍研究生主持的研讨会系列和研究生级别的研讨会课程，其中学生们相互介绍讲座材料。