RUI: New Metathesis Strategies for Organic Synthesis

RUI：有机合成的新复分解策略

• 批准号: 0848128
• 负责人: Kevin Quinn
• 金额: $ 19.63万
• 依托单位: College of the Holy Cross
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-01 至 2013-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0848128&HistoricalAwards=false
• 关键词: RUI; New; Metathesis; Strategies; Organic

The focus of this project is the development of novel approaches to the total synthesis of Annonaceous acetogenin and hydropyranone natural products. The proposed strategies make use of elements of synthetic design (modularity, convergency, two-directional and tandem reaction sequences) that will simplify and provide practical routes to complex molecular structures. In addition to the potential this research offers for the preparation of biologically relevant natural products and analogues, these studies will also assist the ongoing development of important chemical reactions. A particular emphasis is placed on olefin metathesis, and the proposed research includes cross, ring-closing and tandem metathesis processes that will broaden the scope of this powerful methodology and provide insights into factors governing metathesis reactions. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Kevin J. Quinn of the Department of Chemistry at the College of the Holy Cross. Professor Quinn's research efforts are directed at the chemical synthesis of complex natural products, an area of long-standing importance in the pharmaceutical and agricultural industries. This research will provide an ideal training ground for undergraduate coworkers by exposing them to a broad range of experimental and spectroscopic techniques and by requiring them to develop a solid understanding of conceptual and practical aspects of synthetic chemistry.

该项目的重点是开发番荔枝内酯和氢吡喃酮天然产物的全合成新方法。 所提出的策略利用合成设计的元素（模块化，收敛，双向和串联反应序列），这将简化复杂的分子结构，并提供实用的路线。 除了这项研究为制备生物相关的天然产物和类似物提供的潜力外，这些研究还将有助于重要化学反应的持续发展。 特别强调的是烯烃复分解，拟议的研究包括交叉，闭环和串联复分解过程，这将扩大这种强大的方法的范围，并提供对复分解反应的影响因素的见解。 有了这个奖项，有机和高分子化学计划正在支持圣十字学院化学系的Kevin J. Quinn教授的研究。 Quinn教授的研究工作主要针对复杂天然产品的化学合成，这是制药和农业行业长期以来的重要领域。 这项研究将为本科生同事提供一个理想的培训场所，让他们接触到广泛的实验和光谱技术，并要求他们对合成化学的概念和实践方面有深入的了解。