Interparticle Nanoprobes Based on Magnetic Core@Shell Nanoparticles

基于磁性核@壳纳米颗粒的颗粒间纳米探针

• 批准号: 0848701
• 负责人: Chuan-Jian Zhong
• 金额: $ 33万
• 依托单位: SUNY at Binghamton
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2013-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0848701&HistoricalAwards=false
• 关键词: Interparticle; Nanoprobes; Based; Magnetic; Core

Professor Chuan-Jian Zhong of SUNY at Binghamton is supported by the Analytical and Surface Chemistry Program in the Division of Chemistry to study the interparticle structures and properties of magnetic core-shell nanoparticles and assemblies. Methods for the synthesis of magnetic nanoparticle cores of controlled sizes, and for the subsequent coating of the particles with Au and Ag shells of controlled thickness will be developed. The particles will be used as SERS nanoprobes for application in bio-recognition. Functional ligands will be employed to assemble the particles into organized structures to investigate the effects of particle core size, shell composition, core-shell structure, surface ligands, and interparticle interactions on SERS activity. This research addresses the need for core-shell magnetic particles with nanoscale size and surface biocompatibility for applications in biomolecular separations, drug targeting, medical diagnostics, and biosensing. This research will be integrated with educational activities including training of graduate and undergraduate students, and outreach efforts directed at high school students.

纽约州立大学宾汉姆顿分校的Chuan-Jian Zhong教授得到化学系分析和表面化学项目的支持，研究磁性核壳纳米颗粒和组装体的颗粒间结构和性质。 将开发用于合成受控尺寸的磁性纳米颗粒核以及用于随后用受控厚度的Au和Ag壳包覆颗粒的方法。 该粒子将被用作Sers纳米探针，用于生物识别。 功能性配体将被用来组装成有组织的结构的颗粒，研究颗粒的核尺寸，壳的组成，核壳结构，表面配体，和粒子间的相互作用对Sers活性的影响。 这项研究解决了需要核壳磁性粒子的纳米尺寸和表面生物相容性的应用在生物分子分离，药物靶向，医学诊断和生物传感。 这项研究将与教育活动相结合，包括对研究生和本科生的培训，以及针对高中生的推广工作。