Multiplexed and quantitative immunolabelling for cancer diagnostics using gold-silver alloy nanoprobes
使用金银合金纳米探针进行癌症诊断的多重定量免疫标记
基本信息
- 批准号:571982-2022
- 负责人:
- 金额:$ 9.11万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Idea to Innovation
- 财政年份:2022
- 资助国家:加拿大
- 起止时间:2022-01-01 至 2023-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
This proposal aims to introduce new immunolabelling probes based on gold-silver alloy nanoparticles (ANPs) for application in clinical pathology imaging of cancer. Such probes open the possibility to perform quantitative and multiplexed analysis, thus overcoming the important limitations of present immunolabelling techniques. These ANPs can be identified by their spectral signature (colour), enabling multiplexed cell labelling and identification. The ANP labels are stable and bright, and upon modification to bind a specific target, they can enable the biomarker quantification. Such quantification is highly valuable for pathologists who must precisely determine the cancer type and then select the most efficient treatment for the patient, as is needed for immunotherapy. We will mediate the maturation of our research to obtain a robust technology and demonstrate the advantages of antibody-functionalized ANPs as probes for the quantification of PD-L1, a protein biomarker of non-small cell lung cancer. Our approach ought to yield a much higher immunotherapy treatment success rate than is currently available by tailoring treatment specifically toward a patient. The target market segments for this technology are the reagents for immunolabelling (expected to reach USD $2.6 billion in 2026) and the global market for immunotherapy (USD $150 billion). A patent for our ANPs and related process has already been issued (US Patent 10,239,122 (2019)). Moreover, this project also shows potential for the development of new patents for the complete imaging system. Highly respected pathologists, who are potential users in the health sector, have confirmed the value of our new technology and will test it in their own clinical activities. To move our project to commercialization for the synthesis of ANPs, their functionalization, production of the optical imaging setup, and software analysis, the creation of a start-up at Polytechnique Montréal is being considered. Roche, an international leader in in vitro diagnostics, sees tremendous potential in this technology to transform cancer diagnosis and has expressed support for our PD-L1 detection strategy for partnership development.
该提案旨在引入基于金银合金纳米颗粒(ANP)的新型免疫标记探针,用于癌症的临床病理学成像。这种探针打开了进行定量和多重分析的可能性,从而克服了目前免疫标记技术的重要局限性。这些ANP可以通过它们的光谱特征(颜色)来识别,从而实现多路复用的细胞标记和识别。ANP标记物是稳定和明亮的,并且在修饰以结合特定靶标后,它们可以使生物标志物定量成为可能。这种量化对于病理学家来说非常有价值,因为他们必须精确地确定癌症类型,然后为患者选择最有效的治疗方法,这是免疫治疗所需要的。我们将调解我们的研究成熟,以获得一个强大的技术,并证明抗体功能化的ANP作为探针的PD-L1,非小细胞肺癌的蛋白质生物标志物定量的优势。我们的方法应该产生比目前通过专门针对患者定制治疗获得的更高的免疫治疗成功率。该技术的目标细分市场是免疫标记试剂(预计2026年将达到26亿美元)和全球免疫治疗市场(1500亿美元)。我们的ANP和相关工艺的专利已经发布(美国专利10,239,122(2019))。此外,该项目还显示出开发完整成像系统新专利的潜力。备受尊敬的病理学家是卫生部门的潜在用户,他们已经证实了我们新技术的价值,并将在自己的临床活动中进行测试。为了将我们的项目商业化,用于ANP的合成,功能化,光学成像装置的生产和软件分析,正在考虑在蒙特利尔理工学院建立一个初创公司。罗氏是体外诊断领域的国际领导者,看到了这项技术在改变癌症诊断方面的巨大潜力,并表示支持我们的PD-L1检测战略,以促进合作伙伴关系的发展。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Meunier, MichelM其他文献
Meunier, MichelM的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
相似国自然基金
基于SERS纳米标签和光子晶体的单细胞Western Blot定量分析技术研究
- 批准号:31900571
- 批准年份:2019
- 资助金额:24.0 万元
- 项目类别:青年科学基金项目
古菌Ferroplasma sp.在黄铜矿生物浸出中的生态功能
- 批准号:51074195
- 批准年份:2010
- 资助金额:37.0 万元
- 项目类别:面上项目
制冷系统故障诊断关键问题的定量研究
- 批准号:50876059
- 批准年份:2008
- 资助金额:30.0 万元
- 项目类别:面上项目
相似海外基金
Drivers of Political Interference by Military Officers: An Individual-Level Quantitative Analysis
军官政治干预的驱动因素:个人层面的定量分析
- 批准号:
24K16290 - 财政年份:2024
- 资助金额:
$ 9.11万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Conference: Emerging Statistical and Quantitative Issues in Genomic Research in Health Sciences
会议:健康科学基因组研究中新出现的统计和定量问题
- 批准号:
2342821 - 财政年份:2024
- 资助金额:
$ 9.11万 - 项目类别:
Standard Grant
Tools to Control and Monitor Van der Waals Forces between Nanoparticles: Quantitative Insights on Biological, Environmental, and Fungal Cell Interactions.
控制和监测纳米颗粒之间范德华力的工具:对生物、环境和真菌细胞相互作用的定量见解。
- 批准号:
2335597 - 财政年份:2024
- 资助金额:
$ 9.11万 - 项目类别:
Continuing Grant
In situ quantitative monitoring of water environment chemistry and corrosion evolution of steel matrix around typical composite inclusions under different strains
不同应变下典型复合夹杂物周围钢基体水环境化学和腐蚀演化的原位定量监测
- 批准号:
24K17166 - 财政年份:2024
- 资助金额:
$ 9.11万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Quantitative translational neuroscience: Bridging preclinical and human neuroscience research
定量转化神经科学:连接临床前和人类神经科学研究
- 批准号:
MR/Y010698/1 - 财政年份:2024
- 资助金额:
$ 9.11万 - 项目类别:
Fellowship
REU Site: Quantitative Rules of Life: General Theories across Biological Systems
REU 网站:生命的定量规则:跨生物系统的一般理论
- 批准号:
2349052 - 财政年份:2024
- 资助金额:
$ 9.11万 - 项目类别:
Standard Grant
Sixth International Conference on Quantitative Ethnography (ICQE24)
第六届国际定量民族志会议(ICQE24)
- 批准号:
2411957 - 财政年份:2024
- 资助金额:
$ 9.11万 - 项目类别:
Standard Grant
CAREER: Elucidating the fundamental mechanisms of stress corrosion cracking from smooth tensile specimens under constant load for quantitative life-prediction
职业:阐明恒定载荷下光滑拉伸样品应力腐蚀开裂的基本机制,以进行定量寿命预测
- 批准号:
2339696 - 财政年份:2024
- 资助金额:
$ 9.11万 - 项目类别:
Continuing Grant
Exploring the inflammatory mediators degraded by MMP-2 in MMP-2-deficient mice with knee arthritis through a novel TMT-TAILS quantitative proteomics
通过新型 TMT-TAILS 定量蛋白质组学探索 MMP-2 缺陷型膝关节炎小鼠中 MMP-2 降解的炎症介质
- 批准号:
24K19850 - 财政年份:2024
- 资助金额:
$ 9.11万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
QuBIE: Quantitative Biomarker Identification for Non-Endoscopic Prediction and Monitoring of Treatment Response in Eosinophilic Oesophagitis
QuBIE:用于非内镜预测和监测嗜酸性食管炎治疗反应的定量生物标志物鉴定
- 批准号:
10083253 - 财政年份:2024
- 资助金额:
$ 9.11万 - 项目类别:
Collaborative R&D