Fabrication of Helical Mesoporous Silica Tubes with Confined Assembly Process

密闭组装工艺制备螺旋介孔二氧化硅管

• 批准号: 0855322
• 负责人: Jiyu Fang
• 金额: $ 24.61万
• 依托单位: The University of Central Florida Board of Trustees
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2013-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0855322&HistoricalAwards=false
• 关键词: Fabrication; Helical; Mesoporous; Silica; Tubes

0855322 FangThis award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).Helical mesoporous silica is attractive because of its potential applications in chiral catalysis and separations, which are of great interest in the pharmaceutical industry. The objective of this proposed research is to fabricate helical mesoporous silica tubes by the confined assembly of achiral surfactants and tetraethoxysilane (TEOS) inside chiral lipid tubules. The specific aims required to achieve the objective are summarized as follows: (1) synthesize chiral lipid tubules with varying handedness, pitches, diameters and surface charge, (2) fabricate right and left-handed helical mesoporous silica tubes by the confined assembly of achiral surfactants and TEOS inside the chiral lipid tubules of L- and D-enentiomers, (3) alter the pitches of helical mesoporous silica tubes by the confined assembly of achiral surfactants and TEOS inside the chiral lipid tubules with varying helical pitches, (4) change the diameter of helical mesoporous silica tubes by the confined assembly of achiral surfactants and TEOS inside the chiral lipid tubules with different diameters, and (5) correlate the surface charge of chiral lipid tubules with the morphology, helicity, and pore architectures of templated helical mesoporous silica tubes. Intellectual Merit: Chirality plays an important role in biology. By introducing chiral elements into mesoporous silica, new structures and properties can be achieved. Self-assembled chiral lipid tubules provide a unique confinement to assemble achiral surfactants and silica precursors into helical mesoporous silica tubes. The fabrication of single-handed helical mesoporous silica tubes with controllable diameters, handedness, pitches, and pore architectures is particular interested in chiral catalysis and separations. The silica tubes with helical mesoporous walls represent a new hierarchical tubular structure. Three different kinds of surfaces (the out surface, the inner surface of the central tubular cavity, and the mesoporous internal surface of helical walls) may be functionalized differently or act together in helical mesoporous silica tube-integrated chemical systems. The interconnection between the cavity and the mesopores makes helical mesoporous silica tubes attractive for practical applications due to increased capabilities of mass transport. Broad Impacts: A detailed understanding of how the chiral confinement affects the morphologies, sizes, helicity, and pore architectures of templated helical mesoporous silica materials will provide an insight into the mechanism of governing the confined assembly and lead to better design principles in utilizing helical mesoporous silica materials in chiral catalysis and separations. Graduate and undergraduate students, who are involved in this proposed research, will be trained in the interdisciplinary field of materials chemistry, materials processing, and nanotechnology. The outreach activities through NSF Florida Georgia Louis Stokes Alliance for Minorities Participation in Engineering and the Orlando Science Center program will promote the participation of underrepresented groups and high school seniors, which will benefit the broad community. The integration of the proposed research will involve graduate students, undergraduates, and minorities in scientific research and discovery, which is essential for the next generation of scientists and engineers.

0855322 Fang该奖项是根据2009年美国复苏和再投资法案（公法111 - 5）资助的。螺旋介孔二氧化硅因其在手性催化和分离方面的潜在应用而备受关注，这在制药工业中引起了极大的兴趣。本研究的目的是通过非手性表面活性剂和正硅酸乙酯（TEOS）在手性脂质管中的受限组装来制备螺旋介孔二氧化硅管。实现这一目标所需的具体目标概述如下：（1）合成具有不同手性、螺距、直径和表面电荷的手性脂质小管，（2）通过非手性表面活性剂和TEOS在L-和D-对映异构体的手性脂质小管内的受限组装来制造右手和左手螺旋介孔二氧化硅管，（3）通过非手性表面活性剂和正硅酸乙酯在具有不同螺距的手性脂质管内的受限组装来改变螺旋介孔二氧化硅管的螺距，（4）通过非手性表面活性剂和正硅酸乙酯在不同直径的手性脂质管中的受限组装来改变螺旋介孔二氧化硅管的直径，和（5）将手性脂质小管的表面电荷与模板化螺旋介孔二氧化硅管的形态、螺旋度和孔结构相关联。智力优势：手性在生物学中起着重要的作用。通过在介孔氧化硅中引入手性元素，可以获得新的结构和性能。自组装的手性脂质管提供了一个独特的限制组装非手性表面活性剂和二氧化硅前体到螺旋介孔二氧化硅管。具有可控直径、旋向、螺距和孔结构的单手螺旋介孔二氧化硅管的制备在手性催化和分离中特别感兴趣。具有螺旋介孔壁的二氧化硅管代表了一种新的分级管状结构。三种不同类型的表面（外表面、中心管状腔的内表面和螺旋壁的介孔内表面）可以不同地官能化或在螺旋介孔二氧化硅管集成化学系统中一起作用。空腔和介孔之间的互连使得螺旋介孔二氧化硅管由于增加的质量传输能力而对于实际应用具有吸引力。广泛影响：详细了解手性限制如何影响模板化螺旋介孔二氧化硅材料的形态、尺寸、螺旋度和孔结构，将提供对控制限制组装的机制的深入了解，并导致在手性催化和分离中利用螺旋介孔二氧化硅材料的更好的设计原则。研究生和本科生，谁是参与这项拟议的研究，将在材料化学，材料加工和纳米技术的跨学科领域的培训。通过NSF佛罗里达格鲁吉亚路易斯·斯托克斯少数民族参与工程联盟和奥兰多科学中心方案开展的外联活动将促进代表性不足的群体和高中高年级学生的参与，这将使广大社区受益。拟议研究的整合将使研究生、本科生和少数民族参与科学研究和发现，这对下一代科学家和工程师至关重要。