GOALI: Processing and Optimization of Multilayered Pharmaceutical Tablets

该奖项是根据2009年美国复苏和再投资法案（公法111-5）资助的。该项目是德雷克塞尔大学和默克公司之间的合作，解决了多层片剂的加工和优化问题。 多层片剂正在成为共存的医疗条件和多药治疗的关键药物递送方法。 这些片剂在生产和储存过程中往往会裂开。 需要对它们的设计和加工进行基于科学的优化，以确保设计质量。为此，该项目的目标包括：（a）实验探测多层片剂分裂的倾向（B）研究其非线性力学行为，（c）连续和介观尺度模拟界面附近的应力，（d）验证模型预测，以及（e）生成连接工艺参数和多层片剂特性的加工图。两种药物在一个片剂中的组合是在共存条件或组合药物治疗的新疗法的开发中向前迈出的重要一步。 这项工作的结果将促进工业创新和生产力的直接影响到消费者？健康和潜在的成本效益。 该项目将为工业界和学术界提供一个沟通渠道。 默克将为本科生和研究生提供实习机会。 本科生在这个项目的进一步参与将通过在德雷克塞尔的NSF-REU网站梦想实施。默克公司的研究人员将在德雷克塞尔大学休假。年度用户组会议将包括来自PA-NJ-DE地区制药公司的科学家。

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5). This project is a collaboration between Drexel University and Merck Inc & Co and addresses the processing and optimization of multilayered tablets. Multilayer tablets are becoming a key drug delivery method for coexisting medical conditions and multidrug therapies. These tablets tend to split during production and storage. A science-based optimization of their design and processing is needed to ensure quality by design. To this end, the goals of this project include: (a) experimental probing of the propensity of multilayer tablets to splitting (b) study of their nonlinear mechanical behavior, (c) continuum and mesoscale modeling of the stresses near the interface, (d) validation of model prediction, and (e) generation of processing maps that link process parameters and properties of multilayered tablets. The combination of two medications in one tablet is a major step forward in the development of novel therapies of coexisting conditions or combination drug treatments. The results of this work will promote industrial innovation and productivity with direct effects on consumers? health and potential cost benefits. This project will provide a communication conduit between industry and academia. Co-op opportunities for undergraduate and graduate internships will be set-up at Merck. Further involvement of undergraduates in this project will be implemented through the NSF-REU Site DREAM at Drexel. Merck researchers will take industrial sabbaticals at Drexel University. Annual user group meetings will include scientists from pharmaceutical companies in the PA-NJ-DE area.