Smart Autonomous Nanomotors through Orthogonal Self-Assembly

通过正交自组装的智能自主纳米电机

• 批准号: 0901141
• 负责人: Jason Locklin
• 金额: $ 30万
• 依托单位: University of Georgia Research Foundation Inc
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2013-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0901141&HistoricalAwards=false
• 关键词: Smart; Autonomous; Nanomotors; through; Orthogonal

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).The objective of this research is to build a smart nanosystem with the capability of autonomous motion, recognition, and actuation through the orthogonal functionalization of heterostructured nanorods. The approach is to use glancing angle deposition to design heteronanorod backbones, where each functional unit will be integrated onto different spatial locations along backbone in a selective and efficient manner using orthogonal self-assembly. Smart materials and recognition molecules will be used to functionalize the nanomotor backbone to perform autonomous motion and controlled release. Intellectual Merit: This project aims to develop a generic methodology to fabricate and design smart nanosystems that starts to mimic the complex behavior of biological systems. The approach involves: designing heteronanorods with different inorganic and polymeric materials; exploring autonomous propulsion mechanisms that allow for directed motion and photo-responsive polymers for controlled release; and integrating the backbone and functional units. Propulsion mechanisms that are catalytic, photoresponsive, and dissipative will be used to control autonomous motion. Broader Impact: The methodology for nanomotor fabrication and selective functionalization allows the creation of smart nano-functional components and will catalyze rapid and innovative advances in designing and integrating autonomous nanomachines. With further control, implications of those nanomotors in nanoelectromechanical systems, drug delivery, disease treatment, and other areas are anticipated. In addition, the lab-based nanotechnology course module under development by the PIs will help undergraduate and high school students to obtain hands-on experience with nanofabrication. This project also establishes a rigorous physics, chemistry, and nanotechnology education and training opportunity for both graduate and undergraduate students.

该奖项是根据2009年美国复苏和再投资法案(公共法律111-5)资助的。本研究的目标是通过异质纳米棒的正交功能化来构建具有自主运动、识别和驱动能力的智能纳米系统。该方法是使用掠角沉积来设计异构杆主干，其中每个功能单元将利用正交自组装以选择性和高效的方式集成到主干上的不同空间位置。智能材料和识别分子将被用于使纳米电机主干功能化，以执行自主运动和受控释放。智力价值：这个项目旨在开发一种通用的方法来制造和设计智能纳米系统，开始模仿生物系统的复杂行为。该方法包括：用不同的无机和聚合物材料设计异质棒；探索允许定向运动和光响应聚合物进行控制释放的自主推进机制；以及整合主干和功能单元。具有催化、光响应和耗散的推进机制将被用来控制自主运动。更广泛的影响：纳米电机制造和选择性功能化的方法允许创建智能纳米功能组件，并将催化在设计和集成自主纳米机器方面取得快速和创新的进展。随着进一步的控制，这些纳米马达在纳米机电系统、药物输送、疾病治疗和其他领域的应用有望实现。此外，PIS正在开发的以实验室为基础的纳米技术课程模块将帮助本科生和高中生获得纳米制造的实践经验。该项目还为研究生和本科生提供了严格的物理、化学和纳米技术教育和培训机会。