High Resolution Magnetophoresis using Multilayered Magnetic Nanodisks

使用多层磁性纳米盘的高分辨率磁泳

基本信息

  • 批准号:
    0901849
  • 负责人:
  • 金额:
    $ 31.18万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Standard Grant
  • 财政年份:
    2009
  • 资助国家:
    美国
  • 起止时间:
    2009-06-15 至 2013-05-31
  • 项目状态:
    已结题

项目摘要

ECCS-0901849: High Resolution Magnetophoresis Using Multilayered Magnetic NanodisksAbstractThe objective of this research is to demonstrate that a high resolution magnetic multiplexed bioseparation can be achieved by using multilayered magnetic nanodisks as labels. This new magnetophoretic approach allows a continuous separation of sub-100 nm sized magnetic nanodisks according to their distinct magnetic properties.Intellectual Merit: The proposed multilayered nanodisks, consisting of two magnetic layers separated by a non-magnetic layer with two capping layers, can provide a wide-range tunability of magnetic properties, which results in two important advantages over commonly used superparamagnetic iron oxide nanoparticles: opening up the new possibility of magnetic multiplexing and filling the superparamagnetic nanoparticle size gap, from 30 nm to 200 nm, to provide high-moment magnetic labels for bioseparation. In a microfluidic arrangement, these nanodisks will be subjected to a magnetic field varying with time in a triangle wave format. Nanodisks with different saturation fields can be continuously separated. Since magnetic properties of labels and magnetic fields are exactly known, the whole separation process can be easily modeled, which will provide us a convenient tool to optimize conditions for different kind of separations. Broader Impacts: Separation is an important part of any biochemical analysis. The proposed separation method mimics widely-used electrophoresis, but replacing electric field with magnetic field. Magnetic field does not interfere with biological process and materials, and can be applied externally without physical contact between magnet and any liquid. Magnetic forces are independent on ionic strength, pH or surface charges. It can be seen that this proposed approach, if successful, will provide an important alternative for bioseparation. Moreover, it can introduce valuable multiplexing into many highly sensitive detection methods for biosensing. Both of these will have a broad impact in many biological and biomedical research fields. Also, this project offers an outstanding venue to integrate research activities with the education and training for college and graduate students in nanobiotechnology, which is considered as one of the most potentially valuable technologies for U.S. in the global economic competition and for national security. Three experiment modules will be created for a new practicum approach on undergraduate nanobiotechnology teaching; ?experiment-oriented just-in-time teaching?. In addition, through three existing summer camps at UT Arlington, several hundreds of K-12 students will be exposed to this research. Among them, about thirty percent are Hispanic students. The students will certainly be affected positively and may spark their interest in science and engineering.
ECCS-0901849:使用多层磁性纳米盘的高分辨率磁泳摘要本研究的目的是证明通过使用多层磁性纳米盘作为标签可以实现高分辨率磁性多重生物分离。这种新的磁泳方法可以根据其独特的磁特性连续分离亚 100 nm 尺寸的磁性纳米盘。 智力优点:所提出的多层纳米盘由两个磁性层组成,由非磁性层和两个覆盖层隔开,可以提供广泛的磁特性可调性,这与常用的超顺磁性氧化铁相比具有两个重要优势 纳米颗粒:开辟了磁复用的新可能性,并填补了超顺磁性纳米颗粒尺寸差距(从30 nm到200 nm),为生物分离提供高力矩磁性标签。在微流体布置中,这些纳米盘将受到随时间以三角波格式变化的磁场的作用。具有不同饱和场的纳米盘可以连续分离。由于标签的磁特性和磁场是准确已知的,因此可以轻松对整个分离过程进行建模,这将为我们提供一个方便的工具来优化不同类型分离的条件。更广泛的影响:分离是任何生化分析的重要组成部分。所提出的分离方法模仿广泛使用的电泳,但用磁场代替电场。磁场不会干扰生物过程和材料,并且可以从外部施加,无需磁铁与任何液体的物理接触。磁力与离子强度、pH 值或表面电荷无关。可以看出,该方法如果成功,将为生物分离提供重要的替代方案。此外,它可以将有价值的多重技术引入许多高灵敏度的生物传感检测方法中。这两者都将对许多生物和生物医学研究领域产生广泛的影响。此外,该项目还提供了一个将纳米生物技术的研究活动与大学生和研究生的教育和培训相结合的绝佳场所,纳米生物技术被认为是美国在全球经济竞争和国家安全中最具潜在价值的技术之一。将创建三个实验模块,用于本科生纳米生物技术教学的新实践方法; “以实验为导向的即时教学”。此外,通过 UT 阿灵顿分校现有的三个夏令营,数百名 K-12 学生将接触到这项研究。其中,约百分之三十是西班牙裔学生。学生肯定会受到积极的影响,并可能激发他们对科学和工程的兴趣。

项目成果

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Yaowu Hao其他文献

Exciton emissions of CdS nanowire array fabricated on Cd foil by the solvothermal method
溶剂热法在 Cd 箔上制备 CdS 纳米线阵列的激子发射
  • DOI:
    10.1088/1674-1056/abbbf1
  • 发表时间:
    2021
  • 期刊:
  • 影响因子:
    1.7
  • 作者:
    Yong Li;P. Ji;Yaowu Hao;Yueli Song;F. Zhou;Yuan Shuqing
  • 通讯作者:
    Yuan Shuqing
Electroless deposition of Au around electrochemically evolved hydrogen bubbles
  • DOI:
    10.1016/j.electacta.2011.07.002
  • 发表时间:
    2011-10-01
  • 期刊:
  • 影响因子:
  • 作者:
    Chienwen Huang;Yi-Jiun Li;Chivarat Muangphat;Yaowu Hao
  • 通讯作者:
    Yaowu Hao
Green synthesis of multi-dimensional plasmonic coupling structures: Graphene oxide gapped gold nanostars for highly intensified surface enhanced Raman scattering
多维等离子体耦合结构的绿色合成:氧化石墨烯带隙金纳米星用于高度强化的表面增强拉曼散射
  • DOI:
    10.1016/j.cej.2018.05.127
  • 发表时间:
    2018-10
  • 期刊:
  • 影响因子:
    15.1
  • 作者:
    Bin Zhao;Rui Hao;Zhi Wang;Huijuan Zhang;Yaowu Hao;Congyun Zhang;Yaqing Liu
  • 通讯作者:
    Yaqing Liu
Accelerated sintering and microstructural regulation of tungsten powder compact by novel modulation of particle configuration
通过新型颗粒构型调制实现钨粉压坯的加速烧结和微观结构调控
  • DOI:
    10.1016/j.apmate.2025.100317
  • 发表时间:
    2025-10-01
  • 期刊:
  • 影响因子:
    24.900
  • 作者:
    Peng Hu;Yijie Gao;Hexiong Liu;Yunfei Yang;Qinqin Zhou;Jung-Sik Kim;Yaowu Hao;Jinshu Wang
  • 通讯作者:
    Jinshu Wang

Yaowu Hao的其他文献

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{{ truncateString('Yaowu Hao', 18)}}的其他基金

Collaborative Research: Hollow Nanoparticle Synthesis - Templating Electrochemically Evolved Hydrogen Nanobubbles
合作研究:中空纳米颗粒合成——电化学演化氢纳米气泡的模板化
  • 批准号:
    1207377
  • 财政年份:
    2012
  • 资助金额:
    $ 31.18万
  • 项目类别:
    Standard Grant
Collaborative Research: Hierarchically Structured Polycrystalline Hollow Gold Nanoparticles - a Model System for Integrated Experimental and Multiscale Computational Nanomechanics
合作研究:分层结构多晶空心金纳米粒子——集成实验和多尺度计算纳米力学的模型系统
  • 批准号:
    1000831
  • 财政年份:
    2010
  • 资助金额:
    $ 31.18万
  • 项目类别:
    Standard Grant

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磁泳与光动力联合治疗TNBC
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职业:用于芯片实验室应用的铁磁流体微流中的粒子磁泳
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