NSF Postdoctoral Research Fellowship in Biology for FY 2009

2009 财年 NSF 生物学博士后研究奖学金

• 批准号: 0905945
• 负责人: Erin Myers
• 金额: --
• 依托单位: Myers Erin M
• 依托单位国家: 美国
• 项目类别: Fellowship
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0905945&HistoricalAwards=false
• 关键词: NSF; Postdoctoral; Research; Fellowship; Biology

This action funds an NSF Postdoctoral Research Fellowship in Biology for FY 2009 and is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5). The fellowship supports a research and training plan in a host laboratory for the Fellow. The title of the research and training plan for this fellowship to Erin M. Myers is "Comparative genetics of wing shape across Drosophila." This research is being conducted at the University of Houston under the sponsorship of Dr. William A. Frankino. The genetics underlying the expression and evolution of most ecologically or medically important traits is largely unknown. This research uses a variety of approaches in a model system to determine the genetic architecture of interspecific wing shape for several species pairs within the genus Drosophila, as well as the degree of conservation of this architecture. To elucidate this genetic framework, the research integrates geometric morphometrics, quantitative genetics, and comparative genomics to identify the number of genetic regions contributing to interspecific variation in wing shape and the type (e.g. major vs. minor effect, additive vs. non-additive) and magnitude of these effects. In so doing, the project necessitates the development of new software to assist in data acquisition and incorporates novel genotyping and analytical techniques. The research addresses significant questions in evolutionary biology and provides a research template for future studies in non-model systems.As part of the fellowship, training goals include genetic mapping and using model systems. Broader impacts include broad dissemination to the biological community, including advancements in methodology and software to assist in the collection of morphological data as well as mentoring undergraduate students.

本行动根据2009年美国复苏与再投资法案（公法111-5）资助2009年度美国国家科学基金会生物学博士后研究奖学金。奖学金支持奖学金获得者在主办实验室的研究和训练计划。Erin M. Myers的研究和培训计划的标题是“果蝇翅膀形状的比较遗传学”。这项研究是在休斯顿大学由威廉·弗兰基诺博士赞助进行的。大多数生态学或医学上重要特征的表达和进化背后的遗传学在很大程度上是未知的。本研究在一个模型系统中使用了多种方法来确定果蝇属内几个物种对的种间翅膀形状的遗传结构，以及这种结构的保护程度。为了阐明这一遗传框架，该研究整合了几何形态计量学、数量遗传学和比较基因组学，以确定影响翅膀形状和类型（例如主要与次要影响，加性与非加性影响）的种间变异的遗传区域的数量和这些影响的大小。为此，该项目需要开发新的软件来协助数据采集，并结合新的基因分型和分析技术。该研究解决了进化生物学中的重要问题，并为未来非模型系统的研究提供了研究模板。作为奖学金的一部分，培训目标包括基因制图和使用模型系统。更广泛的影响包括广泛传播到生物界，包括方法和软件的进步，以协助形态学数据的收集，以及指导本科生。