Detailing the relation between T2* and tissue pO2 with MR-PHYSIOL to enable unambiguous MR characterization of renal hemodynamics and oxygenation

使用 MR-PHYSIOL 详细说明 T2* 和组织 pO2 之间的关系，以实现肾脏血流动力学和氧合的明确 MR 表征

• 批准号: 192743507
• 负责人: Professorin Dr. Duska Dragun, since 12/2016 (†)
• 金额: --
• 依托单位: Max-Delbrück-Centrum für Molekulare Medizin (MDC) in der Helmholtz-Gemeinschaft
• 依托单位国家: 德国
• 项目类别: Research Units
• 财政年份: 2011
• 资助国家: 德国
• 起止时间: 2010-12-31 至 2019-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/192743507?language=en
• 关键词: Detailing; relation; between; T2; tissue

According to the unifying hypothesis of this Research Unit, renal medullary hypoperfusion and hypoxia play a pivotal role in acute kidney injury (AKI). Although a variety of methods have been developed to assess renal hemodynamics and oxygenation in vivo, a comprehensive analysis has not yet been performed to provide detailed insights into renal medullary hypoperfusion and hypoxia in AKI. The proposal’s ultimate objective is to test the unifying hypothesis by studying renal hemodynamics and oxygenation by means of new multi-modality approach that combines comprehensive advanced Magnetic Resonance Imaging (MRI) techniques in murines with state-of-the-art invasive measurements. The applicants combine the critical expertise required in MRI, renal physiology, and experimental nephrology for this interdisciplinary approach. The applicants will first implement comprehensive quantitative non-invasive renal tissue characterization by parametric MRI-techniques and a setup that combines parametric MRI and established invasive methods in rats in a 9.4 Tesla MR scanner. By applying this multi-modal approach they will characterize regulation of renal hemodynamics and oxygenation by standardised test procedures in healthy rats, and in a rat I/R model of AKI, and later in mice.

根据本研究单位的统一假设，肾髓质灌注不足和缺氧在急性肾损伤（阿基）中起关键作用。尽管已经开发了多种方法来评估体内肾血流动力学和氧合，但尚未进行全面分析以提供对阿基中肾髓质灌注不足和缺氧的详细见解。该提案的最终目标是通过研究肾脏血流动力学和氧合来测试统一假设，该方法采用新的多模态方法，将全面的先进磁共振成像（MRI）技术与最先进的侵入性测量相结合。申请人联合收割机结合了MRI、肾脏生理学和实验肾脏学所需的关键专业知识，以实现这一跨学科方法。申请人将首先在9.4特斯拉MR扫描仪中通过参数MRI技术和结合参数MRI和已建立的大鼠侵入性方法的设置实施全面的定量非侵入性肾组织表征。通过应用这种多模式方法，他们将通过标准化测试程序在健康大鼠、大鼠阿基I/R模型和小鼠中表征肾血流动力学和氧合的调节。

项目成果

Interpretation of functional renal MRI findings: Where physiology and imaging sciences need to talk across domains

功能性肾脏 MRI 结果的解读：生理学和影像科学需要跨领域讨论

• DOI: 10.1002/jmri.25829
• 发表时间: 2018
• 期刊: Journal of Magnetic Resonance Imaging
• 影响因子: 4.4
• 作者: Brix S;Cantow K;Flemming B;Pohlmann A;Niendorf T;Seeliger E
• 通讯作者: Seeliger E

Advancing Cardiovascular, Neurovascular, and Renal Magnetic Resonance Imaging in Small Rodents Using Cryogenic Radiofrequency Coil Technology

• DOI: 10.3389/fphar.2015.00255
• 发表时间: 2015-11-12
• 期刊: FRONTIERS IN PHARMACOLOGY
• 影响因子: 5.6
• 作者: Niendorf, Thoralf;Pohlmann, Andreas;Waiczies, Sonia
• 通讯作者: Waiczies, Sonia

Experimental MRI Monitoring of Renal Blood Volume Fraction Variations En Route to Renal Magnetic Resonance Oximetry

肾磁共振血氧测定过程中肾血容量分数变化的实验 MRI 监测

• DOI: 10.18383/j.tom.2017.00012
• 发表时间: 2017
• 期刊: Tomography
• 影响因子: 1.9
• 作者: Pohlmann A;Cantow K;Huelnhagen T;Grosenick D;Dos Santos Periquito J;Boehmert L;Gladytz T;Waiczies S;Flemming B;Seeliger E;Niendorf T
• 通讯作者: Niendorf T