Stability and Violation of the Lymphoid and Myeloid Dichotomy in the Immune System (L)

免疫系统中淋巴和骨髓二分法的稳定性和破坏 (L)

• 批准号: 193238369
• 金额: --
• 依托单位: Deutsches Krebsforschungszentrum (DKFZ)
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2011
• 资助国家: 德国
• 起止时间: 2010-12-31 至 2014-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/193238369?language=en
• 关键词: Stability; Violation; Lymphoid; Myeloid; Dichotomy

By combining fate mapping approaches and cell transplantations we could demonstrate that tissue macrophages in brain, skin, lung, liver, pancreas and spleen autonomous populations of embryonic or fetal origin. Despite being myeloid lineages, these tissue-resident cells can be distinguished from recruited bone marrow-derived macrophages by a lymphoid fate mapping mark. In the upcoming funding period we plan to expand our studies to identify the embryonic or fetal precursors of tissue macrophages, investigate the homeostasis of tissue macrophages in different organs and analyze the contributions and functions of tissue resident and recruited macrophages under challenge.

通过结合命运定位方法和细胞移植，我们可以证明脑、皮肤、肺、肝、胰腺和脾中的组织巨噬细胞是胚胎或胎儿起源的自主群体。尽管是骨髓谱系，但这些组织驻留细胞可以通过淋巴命运映射标记与募集的骨髓源性巨噬细胞区分开。在即将到来的资助期内，我们计划扩大我们的研究，以确定组织巨噬细胞的胚胎或胎儿前体，研究组织巨噬细胞在不同器官中的稳态，并分析组织驻留和招募的巨噬细胞在挑战下的贡献和功能。