Modulation of sodium/proton exchanger activity by covalent modification and protein interaction (P21)

通过共价修饰和蛋白质相互作用调节钠/质子交换活性 (P21)

• 批准号: 193453565
• 金额: --
• 依托单位: Institut für Biochemie und Molekularbiologie
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2011
• 资助国家: 德国
• 起止时间: 2010-12-31 至 2017-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/193453565?language=en
• 关键词: Modulation; sodium; proton; exchanger; activity

Sodium/proton exchangers are key players in the essential control of intracellular pH and cell volume. The precise modulation of their transport activity is the prerequisite for their distinct functions in a broad spectrum of physiological processes. Their dysfunction is implicated in several diseases including epilepsy, cardiac hypertrophy and cancer. We aim for the elucidation of mechanism and structural basis of sodium/proton exchange activity modulated by the interaction with regulatory proteins and covalent modification with emphasis on the link to Ca2+ signaling to contribute to a detailed understanding of the specific functions of sodium/proton exchangers in health and disease.

钠/质子交换剂是细胞内pH和细胞体积的基本控制中的关键参与者。它们的运输活动的精确调节是它们在广泛的生理过程中的独特功能的先决条件。它们的功能障碍与包括癫痫、心脏肥大和癌症在内的几种疾病有关。我们的目标是阐明与调节蛋白相互作用和共价修饰调节钠/质子交换活性的机制和结构基础，重点是与Ca 2+信号的联系，以有助于详细了解钠/质子交换剂在健康和疾病中的具体功能。