MRI: Acquisition of a 500MHz NMR Spectrometer for Research at California State University Sacramento

MRI：购买 500MHz NMR 波谱仪用于加州州立大学萨克拉门托分校的研究

• 批准号: 0922676
• 负责人: Katherine McReynolds
• 金额: $ 65.51万
• 依托单位: University Enterprises, Incorporated
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-15 至 2012-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0922676&HistoricalAwards=false
• 关键词: MRI; Acquisition; 500MHz; NMR; Spectrometer

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).With this award from the Major Research Instrumentation (MRI) program, Katherine D. McReynolds and colleagues Cynthia J. Kellen-Yuen, Claudia G. Lucero, James A. Miranda and John D. Spence from California State University - Sacramento will acquire a 500 MHz NMR spectrometer and an autosampler for an existing 300 MHz spectrometer. This equipment will support research in 1) the synthesis of glycodendrimers; 2) the synthesis and study of the photoreactivity of highly conjugated arenediynes; 3) the microwave synthesis of nitrogen heterocycles; 4) the study of vinylcyclopropane monoradical cyclization-fragmentation; 5) the synthesis of chiral silyl ethers from ketones and the total synthesis of kavain and 6) the elucidation of the biochemical pathway to the marine neurotoxin domoic acid. The instrumentation will also be used in teaching and training of a diverse group of undergraduate and graduate students at this university.Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in synthetic organic chemistry and biochemistry. This instrument will be an integral part of teaching as well as research.

该奖项是根据2009年美国复苏和再投资法案（公法111-5）资助的。通过主要研究仪器（MRI）项目的奖励，来自加州州立大学萨克拉门托分校的Katherine D. McReynolds和同事Cynthia J. Kellen-Yuen、Claudia G. Lucero、James a . Miranda和John D. Spence将获得一台500 MHz核磁共振光谱仪和一台现有300 MHz光谱仪的自动采样器。该设备将支持以下研究：1)糖树状大分子的合成；2)高共轭芳烃二炔的合成及光反应性研究；3)氮杂环的微波合成；4)乙烯基环丙烷单基环化-破碎的研究；5)酮类合成手性硅醚和全合成kavain； 6)阐明海洋神经毒素软骨藻酸的生化途径。该仪器还将用于该大学本科生和研究生的教学和培训。核磁共振（NMR）波谱是化学家用来研究分子结构的最有力的工具之一。它用于识别未知物质，表征分子内原子的特定排列，以及研究溶液中分子之间相互作用的动力学。获得最先进的核磁共振光谱仪是必不可少的化学家谁正在进行前沿研究。这些核磁共振研究的结果将对合成有机化学和生物化学产生影响。该仪器将成为教学和研究的一个组成部分。