MRI: Acquisition of 3-D Micromanufacturing Instruments for Bioengineering Research at Drexel University

MRI：德雷塞尔大学采购用于生物工程研究的 3D 微制造仪器

• 批准号: 0923173
• 负责人: Hongseok Noh
• 金额: $ 34.43万
• 依托单位: Drexel University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0923173&HistoricalAwards=false
• 关键词: MRI; Acquisition; Micromanufacturing; Instruments; Bioengineering

0923173NohThe goal of this project is to improve the quality and expand the scope of bioengineering research and training at Drexel University by providing shared 3-D micromanufacturing instrumentation. This proposal seeks the acquisition of two complementary 3-D micromanufacturing instruments: a micro stereolithography system and an excimer laser ablation system. Micro stereolithography is an additive 3-D printing technique that can build complex microstructures via a layer-by-layer curing process while excimer laser ablation is a subtractive laser machining technique that can be used for non-planar structures made of various materials such as plastics, glass, metals, ceramics, and semiconductors.Intellectual MeritsTissue engineering research necessitates the capability of building diverse scaffolds with complex 3-D geometries. Biosensors and lab-on-a-chip systems require multi-layer 3-D architecture to effectively integrate and package multiple components. Neuroscience and surgical engineering are in need of multi-functional neural probes and tools that utilize precisely defined 3-D micro-structures. The conventional microfabrication techniques such as photolithography and soft lithography are useful but they are limited to 2-D fabrication and cannot produce complex 3-D structures that are often necessary in bioengineering research activities. The lack of versatile 3-D micromanufacturing tools has hampered many bioengineering research projects at Drexel University. The requested 3-D micromanufacturing instruments will address this need and greatly improve the quality and expand the scope of bioengineering research and training activities, particularly in the areas of bioreactors, in vitro tissue modeling, tissue engineering, biosensors, microfluidics, lab-on-a-chip, biomechanics, biophysics,neuroscience, and surgical engineering.Broader ImpactsCombined with the existing 2-D microfabrication facility, the requested 3-D micromanufacturing instrumentation will provide a powerful and unique microscale manufacturing infrastructure for numerous research activities at Drexel University and in the Greater Philadelphia area. It is anticipated that at least 10 faculty members and 20 graduate students and post-doctoral researchers from 5 departments will become active users of the requested instruments. This shared instrumentation will contribute to improving our ability to recruit and retain outstanding faculty and graduate students (including minority and women) and will increase research funding from both government agencies and the private sector. The requested instruments will also be used in existing and new courses and current outreach programs, providing undergraduate and graduate students, high school teachers and students opportunities to work with state-of-the-art 3-D micromanufacturing instruments.

0923173Noh 该项目的目标是通过提供共享的 3D 微制造仪器来提高德雷塞尔大学生物工程研究和培训的质量并扩大其范围。该提案寻求购买两种互补的 3D 微制造仪器：微型立体光刻系统和准分子激光烧蚀系统。微立体光刻是一种增材3D打印技术，可以通过逐层固化过程构建复杂的微结构，而准分子激光烧蚀是一种减材激光加工技术，可用于由塑料、玻璃、金属、陶瓷和半导体等各种材料制成的非平面结构。 具有复杂 3D 几何形状的支架。生物传感器和芯片实验室系统需要多层 3D 架构来有效集成和封装多个组件。神经科学和外科工程需要利用精确定义的 3D 微结构的多功能神经探针和工具。传统的微加工技术（例如光刻和软光刻）很有用，但它们仅限于 2D 制造，无法产生生物工程研究活动中经常需要的复杂 3D 结构。缺乏通用的 3D 微制造工具阻碍了德雷塞尔大学的许多生物工程研究项目。所要求的3D微制造仪器将满足这一需求，并大大提高生物工程研究和培训活动的质量并扩大其范围，特别是在生物反应器、体外组织建模、组织工程、生物传感器、微流体、芯片实验室、生物力学、生物物理学、神经科学和外科工程等领域。与现有的2D相结合产生更广泛的影响 微制造设施，所需的 3D 微制造仪器将为德雷塞尔大学和大费城地区的众多研究活动提供强大而独特的微尺度制造基础设施。预计来自 5 个系的至少 10 名教职人员和 20 名研究生和博士后研究人员将成为所需仪器的积极用户。这种共享工具将有助于提高我们招募和留住优秀教师和研究生（包括少数族裔和女性）的能力，并将增加政府机构和私营部门的研究经费。所需的仪器还将用于现有和新课程以及当前的推广计划，为本科生和研究生、高中教师和学生提供使用最先进的 3D 微制造仪器的机会。