Radio Frequency Free Electromagnetostatic Dissociation Cell for Tandem Mass Spectrometry

用于串联质谱分析的无射频电磁静离池

• 批准号: 0924027
• 负责人: Valery Voinov
• 金额: $ 66.12万
• 依托单位: Oregon State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2013-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0924027&HistoricalAwards=false
• 关键词: Radio; Frequency; Free; Electromagnetostatic; Dissociation

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).With this award from the Chemistry Research Instrumentation and Facilities: Instrument Development (CRIF:ID) program, Valery Voinov, Douglas Barofsky and Max Deinzer and their research group at Oregon State University will develop a novel electromagnetostatic (EMS) electron capture dissociation (ECD)/collision-induced dissociation (CID) cell for use in tandem mass spectrometry. The proposed EMS cell would be more robust, simpler to implement, require less maintenance than current dissociation cells, which employ designs with rapidly varying electric forces. Voinov and his collaborators will provide their research students (undergraduate and graduate) with training in instrument design and development, and will work with a number of campus programs to highlight the impact of mass spectrometry on a number of areas from forensic science to human health.New kinds of mass spectrometry techniques open up brand new avenues of research. The instrument developed with this award will allow scientists to study the structure of complex molecules with two complementary fragmentation methods in a single collision cell. The instrument to be developed will enable scientists to rapidly determine the complex structures of bio-molecules -- an area of significant practical importance. Increasingly, mass spectrometry has enabled rapid advances in a number of areas with significant societal impact -- from biomedicine to criminalistics. Technology like that developed in the present award will aid in future advances in these and other areas.

该奖项由 2009 年美国复苏和再投资法案（公法 111-5）资助。凭借化学研究仪器和设施：仪器开发 (CRIF:ID) 计划的这一奖项，Valery Voinov、Douglas Barofsky 和 ​​Max Deinzer 及其俄勒冈州立大学的研究小组将开发一种新型电磁静力 (EMS) 电子捕获解离 (ECD)/碰撞诱导解离 (CID) 池用于串联质谱分析。 与当前采用快速变化电力设计的离解电池相比，所提出的 EMS 电池将更坚固、更易于实施，并且需要更少的维护。 Voinov 和他的合作者将为他们的研究生（本科生和研究生）提供仪器设计和开发方面的培训，并将与多个校园项目合作，以强调质谱对从法医学到人类健康等多个领域的影响。新型质谱技术开辟了全新的研究途径。 该奖项开发的仪器将使科学家能够在单个碰撞池中通过两种互补的断裂方法研究复杂分子的结构。 即将开发的仪器将使科学家能够快速确定生物分子的复杂结构——这是一个具有重大实际意义的领域。 质谱技术越来越多地推动了从生物医学到犯罪学等许多具有重大社会影响的领域的快速发展。 本奖项中开发的技术将有助于这些领域和其他领域的未来进步。