Radio Frequency Free Electromagnetostatic Dissociation Cell for Tandem Mass Spectrometry

该奖项由2009年美国复苏和再投资法案（公法111-5）资助。凭借化学研究仪器和设施：仪器开发（CRIF：ID）计划的这一奖项，Valery Voinov，道格拉斯Barofsky和Max Deinzer及其在俄勒冈州州立大学的研究小组将开发一种用于串联质谱的新型电磁（EMS）电子捕获解离（ECD）/碰撞诱导解离（CID）池。 所提出的EMS电池将更稳健，更简单的实施，需要更少的维护比目前的解离电池，采用快速变化的电力的设计。 Voinov和他的合作者将为他们的研究生（本科生和研究生）提供仪器设计和开发方面的培训，并将与许多校园项目合作，突出质谱对法医科学和人类健康等许多领域的影响。新型质谱技术开辟了全新的研究途径。 利用该奖项开发的仪器将允许科学家在单个碰撞池中使用两种互补的碎片化方法研究复杂分子的结构。 即将开发的仪器将使科学家能够迅速确定生物分子的复杂结构-这是一个具有重大实际意义的领域。 越来越多地，质谱分析技术使许多具有重大社会影响的领域-从生物医学到刑事侦查学-取得了迅速进展。 像本奖项中开发的技术将有助于这些和其他领域的未来进步。

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).With this award from the Chemistry Research Instrumentation and Facilities: Instrument Development (CRIF:ID) program, Valery Voinov, Douglas Barofsky and Max Deinzer and their research group at Oregon State University will develop a novel electromagnetostatic (EMS) electron capture dissociation (ECD)/collision-induced dissociation (CID) cell for use in tandem mass spectrometry. The proposed EMS cell would be more robust, simpler to implement, require less maintenance than current dissociation cells, which employ designs with rapidly varying electric forces. Voinov and his collaborators will provide their research students (undergraduate and graduate) with training in instrument design and development, and will work with a number of campus programs to highlight the impact of mass spectrometry on a number of areas from forensic science to human health.New kinds of mass spectrometry techniques open up brand new avenues of research. The instrument developed with this award will allow scientists to study the structure of complex molecules with two complementary fragmentation methods in a single collision cell. The instrument to be developed will enable scientists to rapidly determine the complex structures of bio-molecules -- an area of significant practical importance. Increasingly, mass spectrometry has enabled rapid advances in a number of areas with significant societal impact -- from biomedicine to criminalistics. Technology like that developed in the present award will aid in future advances in these and other areas.