Doctoral Dissertation Improvement: Obstetrical Adaptations in the Human Bony Pelvis: A Morphometric Approach

博士论文改进：人类骨盆的产科适应：形态测量方法

• 批准号: 0925468
• 负责人: Valerie DeLeon
• 金额: $ 1.25万
• 依托单位: Johns Hopkins University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-15 至 2011-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0925468&HistoricalAwards=false
• 关键词: Doctoral; Dissertation; Improvement; Obstetrical; Adaptations

Pelvic morphological variation and sexual dimorphism is of interest to anatomists, anthropologists, and OB/GYNs alike. Sexual differences in pelvic morphology are assumed to relate to the demands of childbirth on females. Recent work has identified these differences in specific areas of the pelvis. However, little is known about how these differences are related to 3D shape changes, how these changes influence the birthing process, and how body size and proportion differences affect these shape changes. Questions addressed in this study include: Are there varying patterns of sexual dimorphism within the pelvis, such that certain areas are more obstetrically influenced than others? Do populations of different body sizes display different patterns of sexual dimorphism?To answer these questions, this study uses cutting-edge geometric morphometric approaches to quantify pelvic morphology. Landmark data will be collected from skeletal collections and from clinical imaging data. Quantitative analyses will determine how pelvic shape varies within and between populations. Intellectual Merit This is one of the first studies to examine obstetrical adaptations within and between populations using geometric morphometrics. Localizing specific areas of the pelvis that are directly influenced by different selective pressures is important for insight into modern human biological adaptation and the patterns and mechanisms of human evolution. Broader ImpactThis study is relevant to a wide range of topics ranging from interpretations of fossil hominins to clinical diagnoses and treatment strategies for pelvic floor disorders. This project involves an interdisciplinary team of anthropologists and clinicians, and will increase dialogue regarding the functional significances of pelvic morphology. Additionally, conclusions from this study will aid in the early identification of women at risk for pelvic floor disorders, which have a negative impact on a woman's quality of life. Funding supports the doctoral dissertation research for a female graduate student

骨盆形态变异和两性异形是解剖学家、人类学家和妇产科医师感兴趣的问题。 骨盆形态的性别差异被认为与分娩对女性的要求有关。 最近的工作已经确定了骨盆特定区域的这些差异。 然而，关于这些差异如何与3D形状变化相关，这些变化如何影响分娩过程，以及身体大小和比例差异如何影响这些形状变化，人们知之甚少。 在这项研究中提出的问题包括：在骨盆内是否有不同的两性异形模式，使得某些区域比其他区域更受产科影响？ 不同体型的种群是否表现出不同的两性异形模式？为了回答这些问题，本研究使用尖端的几何形态测量方法来量化骨盆形态。将从骨骼采集和临床成像数据中收集标志性数据。 定量分析将确定骨盆形状如何在人群内和人群之间变化。 这是第一个研究产科适应人口内和之间使用几何形态测量学。 定位骨盆的特定区域，这些区域直接受到不同选择压力的影响，对于深入了解现代人类的生物适应以及人类进化的模式和机制非常重要。 更广泛的影响这项研究涉及广泛的主题，从化石人类的解释到骨盆底疾病的临床诊断和治疗策略。 该项目涉及一个由人类学家和临床医生组成的跨学科团队，并将增加关于骨盆形态功能意义的对话。 此外，这项研究的结论将有助于早期识别女性盆底疾病的风险，这对女性的生活质量有负面影响。 资助一名女研究生的博士论文研究