The pharmacology of attention in fronto-parietal sensory information processing (C04)

胆碱能系统在视觉皮层感觉反应的注意增强中起重要作用。虽然以前的工作在猕猴V1的毒蕈碱受体亚型的注意增强放电率的强大贡献，我们的最新研究结果表明，这是不是在纹外区MT的情况。我们现在想使用两种有前途的技术来扩展我们的研究，包括其他神经递质系统：微透析（具有有限的时间分辨率，以筛选最有希望的候选递质）和电化学（在40 Hz与电生理记录相结合），以确定注意力的神经药理学基础。

The cholinergic system plays an important role in the attentional enhancement of sensory responses in the visual cortex. Although previous work in macaque V1 has shown a strong contribution of the muscarinic receptor subtype to attentional enhancement of firing rates, our latest results suggest that this is not the case in extrastriate area MT. We now want to use two promising technologies to expand our investigation to include other neurotransmitter systems: microdialysis (with limited time resolution, to screen for the most promising transmitter candidates) and electrochemistry (at 40Hz in combination with electrophysiological recordings), in order to identify the neuropharmacological basis of attention.