Formation of cycloextrin - drug inclusion complexes and scaffolds with the aid of supercritical fluids

0929978 Kiran这是一个探索新方法的研究计划，旨在使用超临界流体与环糊精形成药物包合物，以及形成嵌入药物-环糊精复合物的聚合物基质或支架。超临界流体是可调流体，其可以减少或消除在生物聚合物和药物的合成、纯化和后处理中使用有机溶剂以产生可以用于药物递送或其他医疗装置的颗粒、膜或支架。对于药物递送，药物分子的粒度、形状、形态和晶型非常重要，因为它们影响药物的溶解速率和释放特性。对于支架，多孔性沿着结合抗炎药物和/或生长因子的内置药物释放特征是确保营养物运输、促进细胞增殖和预防器官再生期间感染的重要因素。环糊精具有疏水性内腔，药物分子可以作为客体分子掺入其中。这项研究的一个独特方面是探索开发新的药物-环糊精复合物，使用环糊精的聚合物形式，如具有环糊精侧基的聚合物，其可以在超临界流体介质中形成并直接转化为多孔支架。在可生物降解的聚合物基质如聚（β-己内酯）内形成药物-环糊精包合复合物是另一个新颖的方面，其旨在产生具有内置和/或改善的药物递送特征的组织工程支架。 双药物递送系统联合收割机药物-环糊精基质沿着包埋在可生物降解聚合物基质中的生长因子，被认为是产生新型支架的方法，该支架包含原位药物以最小化炎症和促进器官再生的关键原位生长因子。该研究涉及涉及小（药物）和大（药物）多组分系统的可溶解性和相分离的基础研究。（聚合物）分子和超临界流体混合物（二氧化碳+共溶剂）来理解整体热力学，以及涉及药物分子、环状化合物和具有可以形成包合物的空腔的聚合物的宾主相互作用的纳米尺度动力学。研究旨在了解超临界流体介质中加工的形态学、结晶度和多晶型的后果，以及从这种多组分基质中释放药物的动力学记录。该研究项目汇集了PI在超临界流体和聚合物方面的专业知识，以及联合PI在天然聚合物药物释放和细胞工程系统方面的专业知识。该计划的跨学科性质预计将在从聚合物到传感器的广泛其他应用领域产生广泛的影响，并为具有不同多样性，性别和背景的研究生和本科生创造广泛的教育机会。

0929978KiranThis is a research program on exploration of novel methodologies that aim at using supercritical fluids to form drug inclusion complexes with cyclodextrins, as well as forming polymer matrices or scaffolds that are embedded with drug-cyclodextrin complexes. Supercritical fluids are tunable fluids that can reduce or eliminate the use of organic solvents in synthesis, purification, and post-processing of biopolymers and drugs to generate particles, membranes or scaffolds that can be used in drug delivery or other medical devices. For drug delivery, particle size, shape, morphology and crystal form of the drug molecules are very important as they influence the rate of dissolution and the release characteristics of drugs. For scaffolds, porosity along with built-in drug-release features that incorporate anti-inflammatory drugs and/ or growth factors are important factors that ensure transport of nutrients, promotion of cell proliferation, and prevention of infections during organ regeneration. Cyclodextrins have hydrophobic internal cavities in which drug molecules can be incorporated as guest molecules. A unique aspect of this research is the exploration of development of novel drug-cyclodextrin complexes using polymeric forms of cyclodextrins, such as polymers with pendant cyclodextrin groups, which can be formed and directly transformed into porous scaffolds in supercritical fluid media. Formation of drug-cyclodextrin inclusion complexes within a biodegradable polymer matrix such as poly(å-caprolactone) is another novel aspect that aims at generation of tissue engineering scaffolds with a built-in and/or improved drug delivery feature. Dual drug delivery systems that combine drug-cyclodextrin matrices along with a growth factor embedded in biodegradable polymer matrices are being considered to generate novel scaffolds that incorporate in-situ drugs to minimize inflammation and in-situ growth factors that are critical in promoting organ regeneration.The research involves fundamental studies on miscibility and phase separation in multicomponent systems involving small (drug) and large (polymeric) molecules and supercritical fluid mixtures (carbon dioxide + cosolvent) to understand the overall thermodynamics, and the nano-scale dynamics of guest-host interactions involving drug molecules, cyclic compounds and polymers with cavities that can form inclusion complexes. Studies are directed to understanding the consequences of processing in supercritical fluid media in terms of morphology, crystallinity, and polymorphism as well as documentation of drug release dynamics from such multi-component matrices.The research program brings together the expertise of the PI in supercritical fluids and polymers with the expertise of the co-PI in natural polymer-based drug release and cellular engineering systems. The interdisciplinary nature of the program is expected to have a broad impact in a wide range of other application areas from polymers to sensors, and create broad educational opportunities to graduate and undergraduate students with different diversity, gender and backgrounds.