EXC 1003: Cells in Motion - CiM: Imaging to Understand Cellular Behaviour in Organisms

EXC 1003：运动中的细胞 - CiM：通过成像了解生物体中的细胞行为

• 批准号: 194347757
• 金额: --
• 依托单位: Universität Münster
• 依托单位国家: 德国
• 项目类别: Clusters of Excellence
• 财政年份: 2012
• 资助国家: 德国
• 起止时间: 2011-12-31 至 2018-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/194347757?language=en
• 关键词: EXC; 1003; Cells; Motion; CiM

Dynamic cellular behaviour determines development, tissue homeostasis and regeneration. Optical live imaging strategies have revolutionised our perception of cellular behaviour and have emphasised their dynamic nature, hence "cells in motion". Such optical imaging strategies also highlight the importance of investigating cellular behaviour in intact complex organisms, and the temporo-spatial limitations of current imaging strategies to do so. The same is true for medical imaging, which has been boosted by innovative molecular and functional imaging technologies permitting the clinician to see what he treats. However, specificity and resolution remain limitations. Based on our broad interdisciplinary expertise we are in a unique position to overcome these limitations. We aim to decipher crucial aspects of cellular behaviour in organisms by analysing systems of increasing complexity. Central to our concept is the use and development of novel imaging strategies to optimise temporal-spatial resolution and specificity. Our vision is to establish an interfaculty environment promoting basic biomedical sciences and clinical translation and their interaction using imaging as a common strategy to understand cellular behaviour, regardless of whether this is in cells or tissues, in animal models or in patients. To foster knowledge transfer and scientific creativity we have overcome traditional barriers between faculties by establishing a new "Cells in Motion Interfaculty Centre" (CiMIC) with designated buildings and University of Münsters funding, which is the foundation of the Excellencecluster CiM. Integral to our concept is a new interfaculty educational structure ("Careers in Motion" Centre) that promotes gender equality and diversity, and includes a novel master in "Experimental Medicine" allowing medical students to enter into a structured PhD programme. This will bolster high-quality clinical research and translation of basic science to the clinic.

动态细胞行为决定了发展，组织稳态和再生。光学实时成像策略彻底改变了我们对细胞行为的看法，并强调了它们的动态性质，因此“运动中的细胞”。这种光学成像策略还强调了研究完整复杂生物中细胞行为的重要性，以及当前成像策略的颞空间局限性。医学成像也是如此，这已经通过创新的分子和功能成像技术来提高，允许临床了解他的珍宝。但是，特异性和分辨率仍然有限。根据我们广泛的跨学科专业知识，我们处于克服这些局限性的独特地位。我们的目标是通过增加复杂性的分析系统来破译生物体中细胞行为的关键方面。我们概念的核心是新型成像策略以优化我们的视野的使用和开发是建立一个基于接口的环境，促进基本的生物医学科学和临床翻译及其相互作用，无论是在动物模型还是在动物模型中还是在动物模型中还是在细胞或时间内，都可以使用成像作为一种理解细胞行为的常见策略来理解细胞行为。为了促进知识转移和科学创意，我们通过建立一个新的“运动中心中心中的细胞”（CIMIC）与指定建筑物和穆斯特大学资助，这是卓越集群CIM的基础，从而克服了教职员工之间的传统障碍。我们概念不可或缺的是一种新的界面教育结构（“运动中的职业”中心），可促进性别平等和多样性，并在“实验医学”中包括一个新颖的大师，允许医学生进入结构化的博士学位课程。这将增强基础科学高质量的临床研究以及将基础科学转换为诊所。

项目成果

CD99L2 deficiency inhibits leukocyte entry into the central nervous system and ameliorates neuroinflammation

• DOI: 10.1002/jlb.1a0617-228r
• 发表时间: 2018-10-01
• 期刊: JOURNAL OF LEUKOCYTE BIOLOGY
• 影响因子: 5.5
• 作者: Samus, Maryna;Seelige, Ruth;Vestweber, Dietmar
• 通讯作者: Vestweber, Dietmar

Polarized microtubule dynamics directs cell mechanics and coordinates forces during epithelial morphogenesis

• DOI: 10.1038/s41556-018-0193-1
• 发表时间: 2018-10-01
• 期刊: NATURE CELL BIOLOGY
• 影响因子: 21.3
• 作者: Singh, Amrita;Saha, Tanumoy;Matis, Maja
• 通讯作者: Matis, Maja

Puzzle Approach to Pose Tracking of a Rigid Object in a Multi Camera System

多摄像机系统中刚性物体姿态跟踪的谜题方法

• DOI: 10.1007/978-3-319-23192-1_28
• 发表时间: 2015
• 作者: Schmid S;Jiang X;Schäfers K
• 通讯作者: Schäfers K

Addressable Cholesterol Analogs for Live Imaging of Cellular Membranes.

• DOI: 10.1016/j.chembiol.2018.04.015
• 发表时间: 2018-05
• 期刊: Cell chemical biology
• 影响因子: 8.6
• 作者: L. Rakers;D. Grill;A. L. Matos;S. Wulff;Da Wang;Jonas Börgel;M. Körsgen;H. Arlinghaus;H. Franke;V. Gerke;F. Glorius

Influence of cell shape, inhomogeneities and diffusion barriers in cell polarization models

• DOI: 10.1088/1478-3975/12/6/066014
• 发表时间: 2015-12-01
• 期刊: PHYSICAL BIOLOGY
• 影响因子: 2
• 作者: Giese, Wolfgang;Eigel, Martin;Klipp, Edda
• 通讯作者: Klipp, Edda