Electrical Detection of Protein Binding at DNA Modified Carbon Nanotube Field Effect Transistors

DNA 修饰碳纳米管场效应晶体管上蛋白质结合的电学检测

• 批准号: 0936923
• 负责人: Alon Gorodetsky
• 金额: $ 20万
• 依托单位: Columbia University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0936923&HistoricalAwards=false
• 关键词: Electrical; Detection; Protein; Binding; DNA

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).The Division of Chemistry supports Alon Gorodetsky of Columbia University as an American Competitiveness in Chemistry Fellow. Dr. Gorodetsky will develop chemically modified carbon nanotubes (with attached DNA) to be used in field effect transistors. The suitability of these molecular electronic devices to detect small quantities of proteins will be assessed. Dr. Gorodetsky will conduct experimental work in collaboration with scientists at Columbia University, and will work with theorists at Brookhaven National Laboratory. For his plan for broadening participation, Dr. Gorodetsky will recruit and mentor women chemists from Stern College, Yeshiva University in research to be conducted in the laboratories of Prof. Colin Nuckolls at Columbia University.Research like that of Dr. Gorodetsky is aimed at developing new sensors for biological molecules. The ultimate goal of research like this is to develop improved methods for the rapid detection of important biological molecules (e.g. cancer biomarkers) to aid researchers and clinicians in making measurements quickly and inexpensively. The efforts at broadening participation being pursued by Dr. Gorodetsky are aimed at increasing the participation of young people from underrepresented groups in the sciences.

该奖项是根据2009年美国复苏和再投资法案（公法111-5）资助的。化学系支持哥伦比亚大学的Alon Gorodetsky为美国化学竞争力研究员。Gorodetsky博士将开发化学修饰的碳纳米管（附带DNA），用于场效应晶体管。将评估这些分子电子设备检测少量蛋白质的适用性。Gorodetsky博士将与哥伦比亚大学的科学家合作开展实验工作，并将与布鲁克海文国家实验室的理论家合作。为了扩大参与范围，Gorodetsky博士将从叶史瓦大学（Yeshiva University）斯特恩学院（Stern College）招募并指导女性化学家，让她们在哥伦比亚大学（Columbia University）科林·努科尔斯（Colin Nuckolls）教授的实验室进行研究。Gorodetsky博士这样的研究旨在开发新的生物分子传感器。这类研究的最终目标是开发出快速检测重要生物分子（如癌症生物标志物）的改进方法，以帮助研究人员和临床医生快速、廉价地进行测量。Gorodetsky博士正在进行的扩大参与的努力的目的是增加来自代表性不足群体的年轻人对科学的参与。