Experimental Determination of Chemical Structure in the Undergraduate Curriculum: A Data-Driven Approach

化学(12)尽管X射线结晶学在理解材料和生物分子方面发挥着核心作用，但实验结构测定仍然超出了大多数本科生的经验范围。仪器和计算能力的快速发展创造了这样一种设备，既足够坚固，可以让非专家操作，也足够强大，可以在与教学环境兼容的时间尺度上收集数据。在本科生化学课程的所有层次上，几乎没有什么模型可以将结晶学数据和技术结合起来。这个项目的主要目标是：(1)开发一个将结构方法整合到本科化学课程中的新模式；(2)评估学生在使用实验结构数据时的参与度和学习情况；(3)建立一个本地PUI用户小组，以扩大将X射线衍射方法和资源整合到本科课程中的范围；(4)创建基于网络的互动材料，用于晶体对称学的教学。在地方、区域和国际一级正在进行评估，同时该项目的每个组成部分都解决了对教学结构方法的高质量资源的需求。与STaRBURSTT计算机仪器联盟的联系正被用来建立在以前由NSF支持的将X射线结构方法纳入本科课程的项目的基础上。该项目建立在美国国家科学基金会-CCLI以前的项目NSF-0536710的基础上，“视觉空间学习：基于网络的对称性交互式教程的开发”，并利用了合成无机化学和脂类生物化学方面的教师的专业知识。广泛的影响：该项目正在影响学生和教师：(1)通过课程开发和实施，(2)通过PUI用户群体，(3)通过传播课程产品和他们的评估，(3)通过传播课程产品和他们的评估，以及(4)通过开发基于网络的资源来教授晶体对称性。教师和学生正在通过实验室练习、课程和讲习班接受晶体生长、X射线数据收集和X射线数据分析方面的培训。致力于本科教育的网络共享设施的创建，为俄亥俄州中部地区的教学和本科研究提供了亟需的基础设施。最后，将通过在国家会议上的发言和在一份化学教育期刊上发表文章来传播课程开发项目及其评价的细节。

Chemistry (12)Experimental structure determination remains beyond the experience of most undergraduate students in spite of the central role X-ray crystallography plays in the understanding of materials and biomolecules. Rapid advances in instrumentation and computing power have created equipment that is both rugged enough to allow operation by the non-expert and powerful enough to collect data in a time scale compatible with a teaching environment. Few models exist for the incorporation of crystallographic data and techniques at all levels of the undergraduate chemistry curriculum. The key goals of this project are to: (1) develop a new model for integration of structural methods into the undergraduate chemistry curriculum, (2) assess student engagement and learning when working with experimental structural data, (3) establish a local PUI user group to broaden the incorporation of X-ray diffraction methods and resources into the undergraduate curriculum, and (4) create interactive web-based materials for teaching crystallographic symmetry.Intellectual Merit: The project is creating a model for integration of structural methods into the undergraduate chemistry curriculum. Assessment is occurring at the local, regional and international level while each component of the project addresses the need for high quality resources for teaching structural methods. Connections with the STaRBURSTT CyberInstrumentation Consortium are being used to build on previous NSF-supported projects for the incorporation of X-ray structural methods into the undergraduate curriculum. The project builds upon the PI's previous NSF-CCLI project NSF-0536710, "Visual-Spatial Learning: Development of an Interactive Web-Based Symmetry Tutorial," and makes use of the expertise of faculty in synthetic inorganic chemistry and lipid biochemistry.Broader Impacts: The project is impacting students and faculty (1) locally through curricular development and implementation, (2) regionally through a PUI user group, (3) nationally through dissemination of the curricular products and their assessment, and (4) internationally through the development of web-based resources for teaching symmetry in crystallography. Faculty and students are being trained in aspects of crystal growth, X-ray data collection, and X-ray data analysis through laboratory exercises, courses, and workshops. The creation of a cyber-enabled shared use facility dedicated to undergraduate education is providing much needed infrastructure for teaching and undergraduate research in the central Ohio area. Finally, the details of the curricular development project and its evaluation will be disseminated through presentations at national meetings and publication in a chemical education journal.