SBIR Phase I: 4-Dimensional Optical Tissue Imaging by Variable Digital Illumination

SBIR 第一阶段：通过可变数字照明进行 4 维光学组织成像

• 批准号: 0944376
• 负责人: Jose Melendez
• 金额: --
• 依托单位: Spectral MD Inc
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0944376&HistoricalAwards=false
• 关键词: SBIR; Phase; Dimensional; Optical; Tissue

This Small Business Innovation Research (SBIR) Phase I project will lead to methodologies and systems that extract deep tissue physiological images utilizing novel optical illumination and capture technology. The problem addressed is the challenge of effective and timely analysis of deep tissue physiological processes and their corresponding impact upon human health, wound formation and healing. The opportunity is to provide an affordable and accessible means of identifying critical tissue characteristics in a quantitative fashion thus leading to better clinical guidance and more informed care decisions. The research will identify a set of digital illumination conditions, define model-based transfer functions, and then combine these to construct depth resolved physiological image maps. Illumination patterns will be modeled and evaluated representing a variety of combinations of pattern density, symmetry, geometry and coverage cycles. The resulting image maps and use cases will be compared with established clinical metrics for validation. The project shall lead to a definitive means for extracting depth resolved physiological images.The broader impact/commercial potential of this project is to establish affordable and accessible point of use diagnostic tools utilizing a novel non-contact, optical illumination and imaging modality to gain insights into otherwise non-accessible physiological processes. The innovation will enhance the scientific and technological understanding of the inter-relationships between underlying physiology, hemodynamics, diffuse tissue optics, signal processing, clinical understanding and care. Products to be enabled by variable tissue depth physiological imaging include tools for the effective diagnosis and treatment of the millions of Americans that are impacted annually by debilitating skin conditions caused by cancers, burns, pressure sores or skin transfers. At the same time care providers will realize reduced labor costs and liabilities through more effective identification of wounds. The project's technology advances in real-time, non-invasive optical imaging systems will provide particular benefits to elderly and economically disadvantaged patients who would otherwise suffer from reduced access to adequate diagnosis. Resulting products shall provide greater accessibility to all segments of society to better clinical information that can be used to prevent debilitating wounds and enable more effective wound healing.

这项小企业创新研究（SBIR）第一阶段项目将采用新的光学照明和捕获技术提取深层组织生理图像的方法和系统。解决的问题是有效和及时分析深层组织生理过程及其对人体健康，伤口形成和愈合的相应影响的挑战。机会是提供一种负担得起的和可获得的方法，以定量的方式识别关键的组织特征，从而导致更好的临床指导和更明智的护理决策。该研究将确定一组数字照明条件，定义基于模型的传递函数，然后将它们结合起来构建深度分辨率的生理图像地图。照明模式将被建模和评估，代表各种模式密度、对称性、几何形状和覆盖周期的组合。生成的图像图和用例将与已建立的临床指标进行比较，以进行验证。该项目将产生一种确定的方法来提取深度分辨率的生理图像。该项目的更广泛的影响/商业潜力是建立负担得起的和可访问的使用点诊断工具，利用一种新的非接触式，光学照明和成像模式，以深入了解其他不可访问的生理过程。这项创新将加强对基础生理学、血流动力学、弥漫性组织光学、信号处理、临床理解和护理之间相互关系的科学和技术理解。可变组织深度生理成像的产品包括有效诊断和治疗每年因癌症、烧伤、压疮或皮肤转移引起的皮肤衰弱而受到影响的数百万美国人的工具。同时，护理提供者将通过更有效地识别伤口来减少劳动力成本和责任。该项目的实时、非侵入性光学成像系统的技术进步将为老年人和经济上处于不利地位的患者提供特别的好处，否则他们将无法获得充分的诊断。由此产生的产品将为社会各阶层提供更大的可访问性，以获得更好的临床信息，可用于预防衰弱性伤口并使伤口更有效地愈合。