RUI: Function of C. elegans Tailless in Uterus Development

RUI：无尾线虫在子宫发育中的功能

• 批准号: 0949367
• 负责人: Bruce Wightman
• 金额: $ 37.5万
• 依托单位: Muhlenberg College
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-01 至 2014-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0949367&HistoricalAwards=false
• 关键词: RUI; Function; C.; elegans; Tailless

The Wightman laboratory at Muhlenberg College is studying the mechanisms by which genes direct the formation of organs during animal development. One gene, called tailless plays an important role in directing how the uterus of the microscopic nematode worm Caenorhabditis elegans forms. The lab uses molecular, biochemical and genetic strategies to learn how this gene is controlled by other genes and how it, in turn, controls still other genes. The outcome is a better understanding of the molecular pathway - the series of specific steps - that allows cells to communicate with each other during development to create organized tissues and organs. The tailless gene also exists in vertebrates, including humans, where it functions in the development of stems cells in the brain. Therefore, an understanding of how the nematode tailless gene works helps illuminate the equivalent pathways in other animals. The Wightman laboratory consists of two professional scientists and six to twelve undergraduate students. Therefore, a major impact of this work is to advance education. Students who learn science by participating in scientific research learn more and are well-prepared for careers in science and the clinical professions.

穆伦贝格学院的怀特曼实验室正在研究基因在动物发育过程中指导器官形成的机制。一种叫做无尾的基因在指导微小线虫秀丽隐杆线虫的子宫如何形成方面起着重要作用。该实验室使用分子，生物化学和遗传策略来了解这种基因如何被其他基因控制，以及它如何反过来控制其他基因。结果是更好地理解了分子途径-一系列特定步骤-允许细胞在发育过程中相互交流以创建有组织的组织和器官。无尾基因也存在于包括人类在内的脊椎动物中，它在大脑干细胞的发育中发挥作用。因此，了解线虫无尾基因如何工作有助于阐明其他动物中的等效途径。怀特曼实验室由两名专业科学家和六到十二名本科生组成。因此，这项工作的一个主要影响是促进教育。通过参与科学研究来学习科学的学生可以学到更多，并为科学和临床专业的职业生涯做好充分准备。