EAGER: Sensing of Nanoscale Features by the Living Cells

EAGER：活细胞感知纳米级特征

• 批准号: 0952565
• 负责人: K. Jimmy Hsia
• 金额: $ 5.47万
• 依托单位: University of Illinois at Urbana-Champaign
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0952565&HistoricalAwards=false
• 关键词: EAGER; Sensing; Nanoscale; Features; Living

It is well known that biological materials and systems can perform sensing and actuation functions in a wide range of levels from individual cells to tissues, organisms, and groups of animals. Understanding the mechanisms of such functions in the natural world will enable us to build extremely powerful and versatile engineered systems. This EAGER research proposal aims to understand such sensing mechanisms that govern the interactions between living cells and carbon nanotubes (CNTs). Whether and how living cells could sense and thus respond to the geometrical features at the nanoscale by using a recently discover carbon nanocoils (CNCs) will be examines. The proposed research is a collaborative component with Professor Shuo Hang Chang at National Taiwan University. It is a novel approach to study the biosensing and actuation mechanisms which represents the first step to enable the development of new nano-materials and sensing strategies. It is anticipated that opportunities to tailor material properties at the nanoscale will emerge and applications in bio- and health- or environmentally related areas such as tisue engineering will become possible.

众所周知，生物材料和系统可以在从单个细胞到组织、生物体和动物群体的广泛水平上执行感测和致动功能。了解自然界中这些功能的机制将使我们能够构建非常强大和通用的工程系统。这项EAGER研究计划旨在了解控制活细胞和碳纳米管（CNT）之间相互作用的传感机制。本研究将探讨活体细胞是否以及如何利用新近发现的碳纳米线圈（CNCs）来感知纳米尺度上的几何特征并作出反应。拟议的研究是与国立台湾大学张硕航教授的合作部分。这是一种研究生物传感和驱动机制的新方法，是开发新的纳米材料和传感策略的第一步。 预计在纳米尺度上定制材料特性的机会将出现，并且在生物和健康或环境相关领域（如组织工程）的应用将成为可能。