CAREER: Bimetallic Pd and Ag Catalysts for Electrophilic Trifluoromethylation and Fluorination

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With this CAREER Award, the Chemical Synthesis program is supporting the research of Professor Tobias Ritter of Harvard University. Professor Ritter will apply the knowledge of the structure and reactivity of binuclear transition metal complexes to the development of catalytic carbon-fluorine bond formation. First, an operationally simple synthetic methodology will be developed to effect a silver-catalyzed fluorination of arylstannanes. Second, the silver-catalyzed fluorination reaction will be extended to complex small molecules. Subsequently, other oxidation reactions will be investigated that benefit from the redox participation of two transition metals. Professor Ritter's research could lead to efficient methods for the preparation of fluorine containing organic molecules. These molecules are highly sought after in the development of new pharmaceuticals and agrochemicals. In addition, they are also needed in molecular imaging via positron-emission tomography. Professor Ritter will also initiate educational projects that interweave research and teaching. One project involves an outreach program targeting schools that serve predominantly underrepresented groups. Professor Ritter will travel to different schools as part of a panel of Harvard researchers that will give a general introduction into different opportunities in Chemistry followed by specific guidelines for applying to graduate schools. Another program will focus on establishing early contact to local high school students in the Boston area and educating them about chemistry and science in general.