CAREER: Bimetallic Pd and Ag Catalysts for Electrophilic Trifluoromethylation and Fluorination

职业：用于亲电三氟甲基化和氟化的双金属钯和银催化剂

• 批准号: 0952753
• 负责人: Tobias Ritter
• 金额: $ 55万
• 依托单位: Harvard University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-01 至 2016-02-29
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0952753&HistoricalAwards=false
• 关键词: CAREER; Bimetallic; Pd; Ag; Catalysts

With this CAREER Award, the Chemical Synthesis program is supporting the research of Professor Tobias Ritter of Harvard University. Professor Ritter will apply the knowledge of the structure and reactivity of binuclear transition metal complexes to the development of catalytic carbon-fluorine bond formation. First, an operationally simple synthetic methodology will be developed to effect a silver-catalyzed fluorination of arylstannanes. Second, the silver-catalyzed fluorination reaction will be extended to complex small molecules. Subsequently, other oxidation reactions will be investigated that benefit from the redox participation of two transition metals. Professor Ritter's research could lead to efficient methods for the preparation of fluorine containing organic molecules. These molecules are highly sought after in the development of new pharmaceuticals and agrochemicals. In addition, they are also needed in molecular imaging via positron-emission tomography. Professor Ritter will also initiate educational projects that interweave research and teaching. One project involves an outreach program targeting schools that serve predominantly underrepresented groups. Professor Ritter will travel to different schools as part of a panel of Harvard researchers that will give a general introduction into different opportunities in Chemistry followed by specific guidelines for applying to graduate schools. Another program will focus on establishing early contact to local high school students in the Boston area and educating them about chemistry and science in general.

有了这个职业奖，化学合成项目将支持哈佛大学的托拜厄斯·里特教授的研究。里特教授将把双核过渡金属络合物的结构和反应性知识应用于催化碳-氟键的形成。首先，将开发一种操作简单的合成方法来实现银催化的芳基锡烷氟化。第二，银催化的氟化反应将扩展到复杂的小分子。随后，将研究受益于两种过渡金属参与氧化还原的其他氧化反应。里特教授的研究可能导致制备含氟有机分子的有效方法。这些分子在新药物和农用化学品的开发中受到极大的追捧。此外，它们也是通过正电子发射断层扫描进行分子成像所需要的。里特教授还将发起将研究和教学相结合的教育项目。其中一个项目涉及一项外展计划，目标是服务于主要代表人数不足的群体的学校。里特教授将前往不同的学校，作为哈佛大学研究人员小组的一部分，该小组将对化学领域的不同机会进行一般介绍，然后是申请研究生院的具体指导方针。另一项计划将侧重于与波士顿地区的当地高中生建立早期联系，并对他们进行一般的化学和科学教育。