CAREER: New Catalytic Reactions for Organic Synthesis: Novel Strategies for Cyclopropane Synthesis and Oxidative Carbonylation

职业：有机合成的新催化反应：环丙烷合成和氧化羰基化的新策略

• 批准号: 0953259
• 负责人: Tristan Lambert
• 金额: $ 55万
• 依托单位: Columbia University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2015-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0953259&HistoricalAwards=false
• 关键词: CAREER; New; Catalytic; Reactions; Organic

With this CAREER Award, the Chemical Synthesis program is supporting the research of Professor Tristan Lambert of the Department of Chemistry at Columbia University. Professor Lambert will be developing several new catalytic methods for cyclopropanation and for achieving novel oxidative carbonylations. The first cyclopropanation strategy concerns Lewis acid catalyzed methylene transfer from epoxides or related functionality, and the second concerns direct oxidative cyclopropanation of 1,3-dienes with activated methylene compounds. For carbonylations, novel oxidative carbonylation methods will be developed which provide access to reactive carbonyl functionalities, including acid chlorides and aldehydes. Professor Lambert's research could lead to efficient methods for the preparation of complex organic molecules. These molecules are highly sought after in the development of new pharmaceuticals and agrochemicals. In addition, these compounds are important in any area of activities in which organic chemicals are involved, such as the study of molecular biology. Professor Lambert will also be developing new laboratory experiments aimed at the high school level and designed to increase exposure to and excitement for organic chemistry. These simple yet visually dramatic laboratory experiments will be focused generally on the accessible and fascinating phenomenon of aromaticity and will be accompanied by explanatory literature prepared by Professor Lambert.

有了这个职业奖，化学合成计划是支持教授特里斯坦兰伯特的化学系在哥伦比亚大学的研究。兰伯特教授将开发几种新的催化方法环丙烷化和实现新的氧化羰基化。 第一种环丙烷化策略涉及刘易斯酸催化的环氧化物或相关官能团的亚甲基转移，第二种涉及1，3-二烯与活性亚甲基化合物的直接氧化环丙烷化。 对于羰基化，将开发新的氧化羰基化方法，其提供反应性羰基官能团，包括酰氯和醛。 兰伯特教授的研究可能会导致制备复杂有机分子的有效方法。 这些分子在新药和农用化学品的开发中受到高度追捧。 此外，这些化合物在涉及有机化学品的任何活动领域都很重要，例如分子生物学研究。 兰伯特教授还将开发针对高中水平的新实验室实验，旨在增加对有机化学的接触和兴奋。 这些简单但视觉上引人注目的实验室实验将集中在芳香性的可访问和迷人的现象，并将伴随着兰伯特教授准备的解释性文献。