New Platforms for Catalysis

新的催化平台

• 批准号: 1464992
• 负责人: Tristan Lambert
• 金额: $ 42万
• 依托单位: Columbia University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-01 至 2018-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1464992&HistoricalAwards=false
• 关键词: New; Platforms; Catalysis

With this award, the Chemical Catalysis program of the Division of Chemistry is funding Professor Tristan Lambert of Columbia University to develop new catalysts that improve the construction of complex molecules for areas such as drug discovery and materials research. The catalysts being investigated are expected to increase the efficiency of a variety chemical reactions and also help reduce waste during the synthesis of important molecular targets. A planned approach to student training is in process which makes use of technology and recent findings in educational research to enable students to maximize their self-directed journey to master synthetic chemistry. Graduate students, both within and outside the Lambert group, as well as undergraduate chemistry students, participate in this program, providing these students with both practical and intellectual training in modern organic synthesis, of value for the careers in industry and academe.One aim of this project is the development of a new acid catalyst based on an aromatic cyclopentadienyl anion scaffold, which is thus highly orthogonal to established platforms. The development of a deep understanding of the structure-activity relationship of this platform will set the stage for its application to a range of important problems. The second major aim addresses an unmet challenge in organic synthesis, namely catalysis of carbonyl-olefin metathesis reactions. The proposed plan to develop such catalysts entails two orthogonal strategies, one involving metal catalysis and the other relying on simple organic molecules (organocatalysis). These two approaches represent pioneering investigations into a chemical transformation that has the potential to become a significant enabling technology in fields ranging from small molecule synthesis to materials and beyond. This is a high risk, high payoff aim; this class of reactions is potentially very powerful, as noted, but has resisted attempts at catalysis heretofore.

有了这个奖项，化学系的化学催化计划正在资助哥伦比亚大学的Tristan Lambert教授开发新的催化剂，以改善药物发现和材料研究等领域的复杂分子的构建。 正在研究的催化剂有望提高各种化学反应的效率，并有助于减少重要分子目标合成过程中的浪费。我们现正有计划地训练学生，利用科技和教育研究的最新成果，使学生能最大限度地掌握合成化学。 Lambert小组内外的研究生以及化学专业的本科生都参加了这个项目，为这些学生提供现代有机合成方面的实践和智力培训，对工业和制药业的职业生涯具有价值。这个项目的一个目标是开发一种基于芳香族阴离子支架的新型酸催化剂，其因此与已建立的平台高度正交。 对该平台的结构-活性关系的深入理解的发展将为其应用于一系列重要问题奠定基础。 第二个主要目标解决了有机合成中未满足的挑战，即羰基-烯烃复分解反应的催化。开发此类催化剂的拟议计划需要两种正交策略，一种涉及金属催化，另一种依赖于简单的有机分子（有机催化）。这两种方法代表了对化学转化的开创性研究，该化学转化有可能成为从小分子合成到材料等领域的重要使能技术。这是一个高风险、高回报的目标;如前所述，这类反应可能非常强大，但迄今为止一直抵制催化的尝试。