Group-Transfer Reactions of Low-Coordinate Nickel

化学合成（SYN）计划中的这一奖项支持芝加哥大学的Gregory Hillhouse教授的工作，对各种氧化态的二配位和三配位镍的配位和有机金属化学进行基础研究。该研究的总主题是集中在镍的基团转移反应的探索，特别是那些涉及氮烯，卡宾和氧代官能团，并侧重于了解新的基团转移反应的基本机理细节，并在开发实现这些转换的催化方法。将发展镍的2-配位络合物的化学，包括具有多个金属-配体键合的2-配位络合物的合成方法。主要目标包括具有开壳层电子构型和非整数Ni=E键级的配合物。这项研究将为涉及镍的基团转移反应的化学提供坚实的基本理解，并将影响无机化学和催化以及有机合成的应用领域。这项研究还将提供基本的洞察镍（I）和镍（III），罕见的氧化态，但在催化和生物化学的镍的重要性。除了科学贡献外，该项目还将有助于人力资源开发和下一代科学家和教师的培训，使年轻的同事能够为美国的学术和工业化学研究做出开创性贡献。研究团队将包括所有教育水平的科学家：教师，博士后研究人员，研究生，本科生和高中生。将积极鼓励代表性不足的少数民族的参与，这些少数民族过去包括西班牙裔、非洲裔美国人、视力残疾人和女性同事。

This award in the Chemical Synthesis (SYN) program supports work by Professor Gregory Hillhouse at the University of Chicago to carry out fundamental studies on the coordination and organometallic chemistry of two- and three-coordinate nickel in various oxidation states. The general theme of the research is centered on the exploration of group-transfer reactions of Ni, particularly those involving nitrene, carbene, and oxo functional groups, and is focused on both understanding fundamental mechanistic details of new group-transfer reactions and in developing catalytic methods for effecting these transformations. The chemistry of 2-coordinate complexes of Ni will be developed, including synthetic approaches to 2-coordinate complexes featuring multiple metal-ligand bonding. Key targets include complexes with open-shell electronic configurations and non-integer Ni=E bond orders.This research will provide a solid, fundamental understanding of the chemistry of group transfer reactions involving nickel and will impact applied areas of inorganic chemistry and catalysis, as well as organic synthesis. This research will also provide basic insight into the chemistry of Ni(I) and Ni(III), rare oxidation states but of emerging importance in the catalytic and biological chemistry of nickel. In addition to the scientific contributions, this project will contribute to human resource development and the training of the next generation of scientists and teachers, empowering young coworkers to make seminal contributions to US academic and industrial chemical research endeavors. The research team will include scientists at all educational levels: faculty, postdoctoral researchers, and graduate, undergraduate, and high-school students. Participation of underrepresented minorities, which in the past have included Hispanic, African-American, sight-disabled, and women coworkers, will be actively encouraged.