MRI-R2: Acquisition of a MALDI-TOF Mass Spectrometer

该奖项是根据2009年美国复苏和再投资法案（公法111-5）资助的。通过主要研究和仪器（MRI）项目的奖励，Paramjit S. Arora教授、James W Canary教授和Michael D Ward教授将获得一台MALDI-TOF质谱仪。该仪器将用于大量的研究项目，例如：a)设计合成螺旋作为蛋白质-蛋白质相互作用的抑制剂；b)结构DNA纳米技术；c)活性氧和活性氮与DNA的反应途径；d)晶体中的电荷转移相互作用及其与MALDI质谱的相关性；E)未折叠蛋白的骨架结构；F)蛋白质模拟物——大分子序列特异性杂聚物的合成；G)生物亲和相互作用和微阵列技术；h)光合模式系统的设计、合成和光物理特性。MALDI-TOF质谱仪（基质辅助激光解吸/电离-飞行时间质谱仪系统）通过测量样品中分子组分在质谱仪电离和检测后的质量来鉴定样品的化学成分。MALDI方法提供了一种软电离方法，可以从大分子和生物分子中产生离子，比采用更高能的电离方案更简单。TOF特性是一种根据离子产生后的质量分离离子的分析技术。该仪器将为纽约大学化学系和纽约大学理工学院的核心教师用户以及教学和本科生/研究生研究项目提供结构和成分表征。

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).With this award from the Major Research and Instrumentation (MRI) program, Professor Paramjit S. Arora, James W Canary and Michael D Ward will acquire a MALDI-TOF Mass Spectrometer. The instrument will be used in a large number of research projects, for example: a) the design of synthetic helices as inhibitors of protein-protein interactions; b) structural DNA nanotechnology; c) reaction pathways of reactive oxygen and nitrogen species with DNA; d) charge transfer interactions in crystals and their relevance to MALDI mass spectrometry; e) the structure of the backbone in unfolded proteins; f) protein mimetics - synthesis of macromolecular sequence-specific heteropolymers; g) bioaffinity interactions and microarray technologies; and, h) design, synthesis and photophysical properties of photosynthetic model systems.A MALDI-TOF Mass Spectrometer (matrix assisted laser desorption/ionization - time of flight mass spectrometer system) is used to identify the chemical composition of a sample by measuring the mass of the molecular constituents in the sample after they are ionized and detected by the mass spectrometer. The MALDI method provides a soft ionization method for producing ions from large molecules and biomolecules with less complication than when more energetic ionization protocols are employed. The TOF feature is an analysis technique that separates the ions based on their masses after they are produced. The instrument will provide structural and compositional characterization for a core group of faculty users, as well as the teaching and undergraduate/graduate student research programs, in the NYU Department of Chemistry and the Polytechnic Institute of NYU.