MRI-R2: Acquisition of a MALDI-TOF Mass Spectrometer

该奖项是根据2009年《美国复苏和再投资法案》(Public Law 111-5)资助的。在重大研究和仪器(MRI)计划的这一奖项下，帕罗吉特·S·阿罗拉教授、詹姆斯·W·金丝雀和迈克尔·D·沃德将获得一台MALDI-TOF质谱仪。该仪器将用于大量研究项目，例如：a)设计合成螺旋作为蛋白质-蛋白质相互作用的抑制剂；b)结构DNA纳米技术；c)活性氧和氮物种与DNA的反应途径；d)晶体中的电荷转移相互作用及其与MALDI质谱学的关系；e)未折叠蛋白质的骨架结构；f)蛋白质模拟--合成大分子序列特异的杂聚体；g)生物亲和力相互作用和微阵列技术；光合作用模型系统的设计、合成和光物理性质。MALDI-TOF质谱仪(基质辅助激光解吸/电离飞行时间质谱仪系统)用于通过测量样品中分子组成的质量来鉴定样品的化学组成，样品被电离并被质谱仪检测。MALDI方法为从大分子和生物分子中产生离子提供了一种软电离方法，与使用更高能量的电离协议相比，复杂性较低。飞行时间特征是一种分析技术，它在离子产生后根据它们的质量来分离它们。该仪器将为纽约大学化学系和纽约大学理工学院的核心教师用户群体以及教学和本科生/研究生研究项目提供结构和成分表征。

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).With this award from the Major Research and Instrumentation (MRI) program, Professor Paramjit S. Arora, James W Canary and Michael D Ward will acquire a MALDI-TOF Mass Spectrometer. The instrument will be used in a large number of research projects, for example: a) the design of synthetic helices as inhibitors of protein-protein interactions; b) structural DNA nanotechnology; c) reaction pathways of reactive oxygen and nitrogen species with DNA; d) charge transfer interactions in crystals and their relevance to MALDI mass spectrometry; e) the structure of the backbone in unfolded proteins; f) protein mimetics - synthesis of macromolecular sequence-specific heteropolymers; g) bioaffinity interactions and microarray technologies; and, h) design, synthesis and photophysical properties of photosynthetic model systems.A MALDI-TOF Mass Spectrometer (matrix assisted laser desorption/ionization - time of flight mass spectrometer system) is used to identify the chemical composition of a sample by measuring the mass of the molecular constituents in the sample after they are ionized and detected by the mass spectrometer. The MALDI method provides a soft ionization method for producing ions from large molecules and biomolecules with less complication than when more energetic ionization protocols are employed. The TOF feature is an analysis technique that separates the ions based on their masses after they are produced. The instrument will provide structural and compositional characterization for a core group of faculty users, as well as the teaching and undergraduate/graduate student research programs, in the NYU Department of Chemistry and the Polytechnic Institute of NYU.