MRI-R2: Acquisition of High Throughput Crystallization and Collection Devices

MRI-R2：获取高通量结晶和收集设备

• 批准号: 0959778
• 负责人: ChulHee Kang
• 金额: $ 149.72万
• 依托单位: Washington State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-02-01 至 2013-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0959778&HistoricalAwards=false
• 关键词: MRI; R2; Acquisition; Throughput; Crystallization

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).This Major Research Instrumentation-Recovery and Reinvestment (MRI-R2) award funds the acquisition of high throughput crystallization and collection devices at the Biomolecular X-ray Crystallography (BXC) Center at Washington State University (WSU). Research benefitting from the acquisition includes projects to investigate mechanisms of DNA damage and repair, reproductive physiology, defense against bioterrorism, causes and prevention of major worldwide diseases, plant defense systems, redox chemistry, protein folding, production of food and renewable energy, and reduction of environmental pollution. Automation of crystallization and availability of high flux X-ray generators with dual wavelengths (Cu and Cr anodes) has significantly enhanced the overall scientific, and establishes the BXC Center as a regional center for high-throughput structure determination. The availability of the high throughput devices allows the BXC Center to not only continuously address the most compelling scientific questions in each of those on-going collaborations but also allows expansion of the collaborations and services to include new neighboring institutes. The instrumentation provides extended and efficient service for the regional research and teaching community to collectively enhance their scientific programs via access to and utilization of a core. The BXC Center performs numerous services and external collaborations with many institutions across the Nation, and is active in enhancing regional teaching and training capabilities at the graduate, undergraduate, and high school level through laboratory experiments and classroom instruction. The high throughput devices increases the Center's role in this region to produce world-class scientists of the next generation derived from diverse economic, ethnic and geographic backgrounds. Results from the studies enabled by the new equipment are disseminated by student and faculty presentations at regional and national meetings, and through publication in peer-reviewed journals.

该奖项是根据2009年的《美国回收与再投资法》（公法111-5）资助的。本主要的研究仪器恢复和再投资（MRI-R2）奖基金在华盛顿州立大学（WSU）（WSU）的生物分子X射线晶体学（BXC）中心的生物分子X射线晶体学（BXC）中心收购了高吞吐量结晶和收集设备。从收购中受益的研究包括研究DNA损伤和修复机制，生殖生理学，对生物恐怖主义的防御，原因和预防主要全球疾病的原因和预防，植物防御系统，氧化还原化学，蛋白质折叠，食物的产生和可再生能源以及对环境污染的减少。具有双波长（CU和CR阳极）的高通量X射线发电机的结晶自动化和可用性显着增强了整体科学，并确立了BXC中心作为高通量结构确定的区域中心。高通量设备的可用性使BXC中心不仅可以在每个正在进行的协作中不断地解决最引人注目的科学问题，而且还可以扩展协作和服务，以包括新的相邻机构。该仪器为区域研究和教学社区提供了扩展，有效的服务，以通过访问和利用核心来共同增强其科学计划。 BXC中心与全国许多机构进行了众多服务和外部合作，并积极通过实验室实验和课堂教学来增强研究生，本科和高中级的区域教学和培训能力。高吞吐量设备增加了该中心在该地区的作用，以产生来自多样化的经济，种族和地理背景的下一代世界一流的科学家。新设备所启用的研究的结果是在区域和国家会议上的学生和教职员工演讲传播的，以及通过同行评审期刊的出版。