MRI-R2: Acquisition of High Throughput Crystallization and Collection Devices

MRI-R2：获取高通量结晶和收集设备

• 批准号: 0959778
• 负责人: ChulHee Kang
• 金额: $ 149.72万
• 依托单位: Washington State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-02-01 至 2013-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0959778&HistoricalAwards=false
• 关键词: MRI; R2; Acquisition; Throughput; Crystallization

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).This Major Research Instrumentation-Recovery and Reinvestment (MRI-R2) award funds the acquisition of high throughput crystallization and collection devices at the Biomolecular X-ray Crystallography (BXC) Center at Washington State University (WSU). Research benefitting from the acquisition includes projects to investigate mechanisms of DNA damage and repair, reproductive physiology, defense against bioterrorism, causes and prevention of major worldwide diseases, plant defense systems, redox chemistry, protein folding, production of food and renewable energy, and reduction of environmental pollution. Automation of crystallization and availability of high flux X-ray generators with dual wavelengths (Cu and Cr anodes) has significantly enhanced the overall scientific, and establishes the BXC Center as a regional center for high-throughput structure determination. The availability of the high throughput devices allows the BXC Center to not only continuously address the most compelling scientific questions in each of those on-going collaborations but also allows expansion of the collaborations and services to include new neighboring institutes. The instrumentation provides extended and efficient service for the regional research and teaching community to collectively enhance their scientific programs via access to and utilization of a core. The BXC Center performs numerous services and external collaborations with many institutions across the Nation, and is active in enhancing regional teaching and training capabilities at the graduate, undergraduate, and high school level through laboratory experiments and classroom instruction. The high throughput devices increases the Center's role in this region to produce world-class scientists of the next generation derived from diverse economic, ethnic and geographic backgrounds. Results from the studies enabled by the new equipment are disseminated by student and faculty presentations at regional and national meetings, and through publication in peer-reviewed journals.

该奖项是根据2009年美国复苏和再投资法案（公法111-5）资助的。该主要研究仪器-回收和再投资（MRI-R2）奖资助华盛顿州立大学（WSU）生物分子x射线晶体学（BXC）中心购买高通量结晶和收集设备。受益于此次收购的研究项目包括研究DNA损伤和修复机制、生殖生理学、防御生物恐怖主义、全球主要疾病的起因和预防、植物防御系统、氧化还原化学、蛋白质折叠、食品和可再生能源的生产以及减少环境污染。结晶自动化和双波长（Cu和Cr阳极）高通量x射线发生器的可用性显著提高了整体科学水平，并使BXC中心成为高通量结构测定的区域中心。高通量设备的可用性使BXC中心不仅可以在每个正在进行的合作中持续解决最引人注目的科学问题，而且还可以扩展合作和服务，包括新的邻近研究所。该仪器为区域研究和教学团体提供了扩展和有效的服务，通过访问和利用核心来共同提高他们的科学计划。BXC中心与全国许多机构开展了许多服务和外部合作，并积极通过实验室实验和课堂教学提高区域研究生，本科生和高中水平的教学和培训能力。高通量设备增加了中心在该地区的作用，以培养来自不同经济，种族和地理背景的下一代世界级科学家。由新设备促成的研究成果通过学生和教师在区域和国家会议上的发言以及在同行评议的期刊上发表的方式传播。