MRI: Collaborative: Development of a novel pediatric magnetoencephalography (MEG) system

MRI：协作：开发新型儿科脑磁图 (MEG) 系统

• 批准号: 0958669
• 负责人: Matti Hamalainen
• 金额: $ 99.23万
• 依托单位: Massachusetts General Hospital
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2013-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0958669&HistoricalAwards=false
• 关键词: MRI; Collaborative; Development; novel; pediatric

"This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5)." Support from the National Science Foundation will enable Drs. Ellen Grant and Yoshio Okada at Children's Hospital Boston (CHB) and Dr Matti Hämäläinen at Massachusetts General Hospital (MGH) to develop a novel magnetoencephalography (MEG) system, babyMEG, optimized for the non-invasive study of human brain development from premature babies up to children 3 years old. This new instrument will be developed under the direction of Dr. Okada in collaboration with an R&D company (Tristan Technologies) in San Diego, CA. The software for data analysis will be developed by Dr. Hämäläinen. Once completed, the instrument will be installed in a novel clinical/research facility that CHB has committed to build next to the Neonatal and Pediatric Intensive Care Units (NICU and PICU). The PI of this project (Dr. Grant) will oversee the use of the babyMEG in this facility as its Center Director. This babyMEG is transformative because it will have a tremendous impact on the understanding of early brain development in humans. Users will be able to measure cortical activity with an unprecedented level of sensitivity and spatial resolution: high-resolution information about regional cortical activity in real time in the developing brain will become available. This information will allow evaluation of developing functional brain connectivity with acquisition of new skills such as language and determination of how developing connectivity is altered by disease. The new research facility where this work will be carried out will be equipped with other neuroimaging tools such as a state-of-the-art 3 Tesla MR scanner with custom-built 32-channel head coils and a novel Near Infrared Spectroscopy (NIRS) system. Thus, the babyMEG will be part of a multimodal neuroimaging facility. The proximity of the research center to the NICU and PICU is unique in the world. This infrastructure will provide exciting opportunities for understanding human brain development in health and disease and for eventually helping to maximize the potential of babies with various brain disorders. It is anticipated that the support from the NSF will help to create a unique research center that will become an important hub for research, training and education not only in this country, but also in the world. The center will be used for training of postdoctoral fellows, graduate and undergraduate students as well junior faculty from engineering and neuroscience. The babyMEG in the clinical environment will expose basic scientists to the real world problems and questions of early brain development and clinicians to the relevance of basic science methods. The babyMEG will promote not only interdisciplinary research but also collaboration between multiple Harvard institutions including CHB, MGH, MIT and Harvard Medical School as well as their collaborators worldwide. Specific benefits to graduate education will focus on training students to research scientific questions drawing on advice and guidance from the three co-PIs and senior faculty members who will be using the facility in collaboration with the three key leaders. Use of the babyMEG will be promoted through regular hands-on teaching sessions, seminar series and public lectures.

该奖项是根据2009年《美国复苏和再投资法案》(公法111-5)资助的。在国家科学基金会的支持下，波士顿儿童医院(CHB)的Ellen Grant和Yoshio Okada博士以及马萨诸塞州综合医院(MGH)的Matti HämäLäinen博士将开发一种新型的脑磁图(MEG)系统BabyMEG，该系统优化了从早产儿到3岁儿童的人脑发育的非侵入性研究。这种新仪器将在冈田博士的指导下，与位于加利福尼亚州圣地亚哥的一家研发公司(特里斯坦技术公司)合作开发。数据分析软件将由HämäLäinen博士开发。一旦建成，该仪器将被安装在CHB承诺在新生儿和儿科重症监护病房(NICU和PICU)旁边建造的一个新的临床/研究设施中。该项目的PI(Grant博士)将作为中心主任监督该设施中BabyMEG的使用。这个婴儿脑电是变革性的，因为它将对人类早期大脑发育的理解产生巨大影响。用户将能够以前所未有的灵敏度和空间分辨率测量皮质活动：有关发育中大脑区域皮质活动的实时高分辨率信息将变得可用。这些信息将通过获得语言等新技能来评估正在发展的大脑功能连接性，并确定疾病如何改变正在发展的连接性。这项工作将在新的研究设施中进行，该设施将配备其他神经成像工具，例如最先进的3特斯拉磁共振扫描仪，带有定制的32通道头线圈和新型近红外光谱(NIRS)系统。因此，BabyMEG将成为多模式神经成像设施的一部分。研究中心距离NICU和PICU的距离在世界上是独一无二的。这一基础设施将为了解人类大脑在健康和疾病方面的发展提供令人兴奋的机会，并最终帮助最大限度地发挥患有各种大脑疾病的婴儿的潜力。预计来自NSF的支持将有助于创建一个独特的研究中心，它将成为美国乃至世界研究、培训和教育的重要中心。该中心将用于培训博士后研究员、研究生和本科生以及工程学和神经科学的初级教员。临床环境中的BabyMEG将使基础科学家接触到现实世界中的问题和早期大脑发育的问题，并使临床医生接触到基础科学方法的相关性。BabyMEG不仅将促进跨学科研究，还将促进包括CHB、MGH、MIT和哈佛医学院在内的多个哈佛大学机构以及它们在世界各地的合作者之间的合作。研究生教育的具体好处将集中在培训学生研究科学问题，借鉴三位共同绩效负责人和高级教员的建议和指导，他们将与三位主要领导人合作使用该设施。将通过定期的实践教学课程、系列研讨会和公开讲座来推广婴儿MEG的使用。