MRI-R2: Acquisition of an Time of Flight Mass Spectrometry System for Interdisciplinary Research and Training at the University of Houston-Clear Lake

该奖项是根据2009年美国复苏和再投资法案（公法111-5）资助的。来自休斯顿大学清湖分校的王泽荣博士、Lory Z. Santiago-Vazquez教授和张春龙教授将获得一台配备电喷雾电离源（ESI）的液相色谱飞行时间质谱仪（LC-TOF-MS）。该仪器将支持他们的研究，包括核苷类似物的开发，可能导致潜在的抗癌和抗艾滋病毒药物，修复系统的设计，以支持绿色和可持续的环境，以及生产具有生物活性的海洋天然产品。休斯顿大学克利尔湖分校的其他七名教员将受益于他们在蛋白质和核酸以及有机和有机金属化合物方面的研究。质谱法（MS）是通过测量样品中分子组分电离后经质谱仪检测后的质量，来鉴定样品的化学成分。色谱入口将在分析每种成分之前提供复杂混合物的分离。飞行时间质量分析仪具有较高的灵敏度和质量精度，有助于分析和解释所得数据。通过在研究和实验课程中使用LC/MS，学生将在生物学、化学和环境科学等学科的各种应用中获得这种现代仪器的宝贵经验。

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).With this award from the Major Research and Instrumentation (MRI) program, Professors Zerong D. Wang, Lory Z. Santiago-Vazquez and Chunlong Zhang from the University of Houston at Clear Lake will acquire a liquid chromatography time-of-flight mass spectrometer (LC-TOF-MS) equipped with an electrospray ionization source (ESI). The instrumentation will support their research in the development of nucleoside analogs that may lead to potential anticancer and anti-HIV drugs, the design of remediation systems to support a green and sustainable environment, and the production of marine natural products with biological activity. Seven other faculty members at the University of Houston-Clear Lake will benefit in their studies of proteins and nucleic acids as well as organic and organometallic compounds.Mass spectrometry (MS) is used to identify the chemical composition of a sample by measuring the mass of the molecular constituents in the sample after they are ionized and detected by the mass spectrometer. The chromatography inlet will provide separation of complex mixtures before each component is analyzed. The time of flight mass analyzer has high sensitivity and mass accuracy to assist the analyses and interpretation of the resultant data. By using the LC/MS in research and laboratory courses, students will gain valuable experience with this modern instrument in a variety of applications across the disciplines of biology, chemistry, and environmental sciences.