MRI-R2: Acquisition of a 400 MHz NMR Spectrometer at Chicago State University

MRI-R2：在芝加哥州立大学购买 400 MHz NMR 波谱仪

• 批准号: 0958939
• 负责人: LeRoy Jones II
• 金额: $ 28万
• 依托单位: Chicago State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0958939&HistoricalAwards=false
• 关键词: MRI; R2; Acquisition; 400; MHz

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).With this award from the Major Research Instrumentation (MRI) program Professor LeRoy Jones II and colleagues Elmer J. Gentry, Asare Nkansah, Melany P. Puglisi-Weening and Felix M. Rivas from the Departments of Chemistry and Physics at Chicago State University will acquire a 400 MHz NMR spectrometer with variable temperature capabilities. The instrument will be used to support research activities such as: 1) preparation of chiral transition metal catalysts for olefin metathesis reactions; 2) development of dendrimers and polymers for drug delivery; 3) synthesis of antibacterial peptides; 4) synthetic modification of antimicrobial compounds for altered spectrum and potency; 5) antimicrobial chemical defenses of marine plants and algae; and 6) isolation and characterization of the CNS-active constituents of nutmeg.Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in synthetic organic/inorganic chemistry, materials chemistry and biochemistry. This instrument will be an integral part of teaching as well as research.

该奖项根据 2009 年《美国复苏和再投资法案》（公法 111-5）提供资金。通过主要研究仪器 (MRI) 计划的这一奖项，芝加哥州立大学化学系和物理系的 LeRoy Jones II 教授及其同事 Elmer J. Gentry、Asare Nkansah、Melany P. Puglisi-Weening 和 Felix M. Rivas 将购买一台 400 MHz NMR 波谱仪， 可变温度能力。该仪器将用于支持以下研究活动：1）用于烯烃复分解反应的手性过渡金属催化剂的制备； 2）用于药物输送的树枝状聚合物和聚合物的开发； 3）抗菌肽的合成； 4) 抗菌化合物的合成修饰以改变谱和效力； 5）海洋植物和藻类的抗菌化学防御； 6) 肉豆蔻中的 CNS 活性成分的分离和表征。核磁共振 (NMR) 光谱是化学家阐明分子结构的最强大工具之一。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于进行前沿研究的化学家来说，使用最先进的核磁共振波谱仪至关重要。这些核磁共振研究的结果将对合成有机/无机化学、材料化学和生物化学产生影响。该仪器将成为教学和研究不可或缺的一部分。