MRI-R2: Acquisition of a 400 MHz Nuclear Magnetic Resonance (NMR) Spectrometer

MRI-R2：获取 400 MHz 核磁共振 (NMR) 波谱仪

• 批准号: 0959322
• 负责人: J. Thomas Ippoliti
• 金额: $ 24.6万
• 依托单位: University of St. Thomas
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2013-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0959322&HistoricalAwards=false
• 关键词: MRI; R2; Acquisition; 400; MHz

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).With this award from the Major Research Instrumentation (MRI) program Professor J. Thomas Ippoliti and colleagues Bartholomew Dahl, Thomas C. Marsh and William H. Ojala from the University of St. Thomas will acquire a 400 MHz nuclear magnetic resonance (NMR) spectrometer with an autosampler unit. The instrument will be used to support research activities such as: 1) design and synthesis of oxazolidinone antimicrobial agents, photochromic naphthopyrans and biodegradable polylactides capable of adhering to metal stents, 2) exploration of use of a tethering lactone unit in the design and synthesis of biaryl molecular switches, 3) examination of nucleic acid nanoscaffolds containing a single guanine-rich oligonucleotide sequence motif, and 4) co-crystallization of isostructural pairs of "bridge-flipped" benzylideneanilines and phenylhydrazones.Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in synthetic organic/inorganic chemistry, materials chemistry and biochemistry. This instrument will be an integral part of teaching as well as research.

该奖项是根据2009年美国复苏和再投资法案（公法111-5）资助的。作者声明：William H.来自圣托马斯大学的Ojala将获得一台带有自动进样器的400 MHz核磁共振（NMR）光谱仪。该工具将用于支持研究活动，例如：1）设计和合成恶唑烷酮抗微生物剂、光致变色萘并吡喃和能够粘附到金属支架上的可生物降解的聚交酯，2）探索栓系内酯单元在联芳基分子开关的设计和合成中的用途，3）检测含有单个富含鸟嘌呤的寡核苷酸序列基序的核酸纳米支架，（4）“桥翻转”苯亚甲基苯胺和苯腙的同构对的共结晶。核磁共振（NMR）光谱是化学家用来阐明分子结构的最有力的工具之一。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于从事前沿研究的化学家来说，使用最先进的NMR光谱仪是必不可少的。这些NMR研究的结果将对合成有机/无机化学、材料化学和生物化学产生影响。该仪器将成为教学和研究的一个组成部分。