MRI-R2: Acquisition of a High-Resolution Time-of-Flight Mass Spectrometer for Research and Education

MRI-R2：购买高分辨率飞行时间质谱仪用于研究和教育

• 批准号: 0959621
• 负责人: Ruth Ann Armitage
• 金额: $ 20.73万
• 依托单位: Eastern Michigan University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0959621&HistoricalAwards=false
• 关键词: MRI; R2; Acquisition; Resolution; Time

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).With this award from the Major Research Instrumentation (MRI) program Professor Ruth Ann Armitage and colleagues Gavin Edwards, Cory D Emal, Harriet A Lindsay and John Texter from the Department of Chemistry at Eastern Michigan University will acquire a high-resolution time-of-flight (TOF) mass spectrometer with direct acquisition in real time (DART) and electrospray ionization (ESI) sources. The instrument will be used to support research activities such as: 1) method development for rapid, non-destructive characterization of organic cultural heritage materials in works of art; 2) isolation, identification, and synthesis of biologically relevant molecules such as polyphenols; 3) atmospheric chemistry of biogenic, volatile organic compounds; 4) development of microwave-assisted reaction methodology; 5) advanced materials such as porous co-polymers from ionic liquids; 6) identification of end-groups in self-assembling block copolymeric materials; 7) signal transduction pathways in the regulation of normal and cancer cell growth and proliferation; 8) determination of microbial metabolites in rat cecal fluid and in vitro co-cultures; and 9) insulin-based inhibitors of human islet amyloid polypeptide.Mass spectrometry (MS) is an analytical technique used by chemists and biochemists to identify the chemical composition of a sample and its purity. TOF-mass spectrometry with ionization capabilities is an excellent technique for obtaining accurate molecular weights on small and large molecules. Use of this type of mass spectrometer has become a standard technique, especially in studies involving labile molecules. This research will have a significant impact in a number of areas, especially chemistry, materials chemistry, the environment and biochemistry as well as in the preservation of works of art. This instrument will be an integral part of teaching as well as research.

该奖项是根据2009年美国复苏和再投资法案资助的（公法111-5）。凭借这项由主要研究仪器（MRI）计划教授露丝·安·阿米蒂奇和同事加文·爱德华兹、科里·D·埃马尔颁发的奖项，东密歇根大学化学系的哈里特（Harriet A）、林赛（Lindsay）和约翰·泰克斯特（John Texter）将获得高分辨率飞行时间（TOF）具有真实的时间直接采集（DART）和电喷雾电离（ESI）源的质谱仪。该仪器将用于支持以下研究活动：1）开发方法，以快速、非破坏性地表征艺术品中的有机文化遗产材料; 2）分离、鉴定和合成多酚等生物相关分子; 3）生物挥发性有机化合物的大气化学; 4）开发微波辅助反应方法; 5）先进材料，如来自离子液体的多孔共聚物; 6）自组装嵌段共聚物材料中端基的鉴定; 7）正常和癌细胞生长和增殖调节中的信号转导途径; 8）大鼠盲肠液和体外共培养物中微生物代谢物的测定;和9）人胰岛淀粉样多肽的基于胰岛素的抑制剂质谱（MS）是化学家和生物化学家用于鉴定样品的化学组成及其纯度的分析技术。具有电离能力的TOF质谱法是用于获得小分子和大分子的精确分子量的优秀技术。使用这种类型的质谱仪已成为标准技术，特别是在涉及不稳定分子的研究中。这项研究将在许多领域产生重大影响，特别是化学，材料化学，环境和生物化学以及艺术品的保存。