MRI-R2: Development of an Instrument for Information Science and Computing in Neuroscience

MRI-R2：神经科学信息科学和计算仪器的开发

• 批准号: 0959985
• 负责人: Malek Adjouadi
• 金额: $ 293.95万
• 依托单位: Florida International University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2015-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0959985&HistoricalAwards=false
• 关键词: MRI; R2; Development; Instrument; Information

"This award is funded under the American Recovery and Reinvestment Act of 2009(Public Law 111-5)."Proposal #: 09-59985PI(s): Adjouadi, Malek; Barreto, Armando B.; Gaillard,William; Jayakar,Prasanna; Rishe, Naphtali D.Institution: Florida International University Title: MRI-R2/Dev: Instrument for Information Science and Computing in NeuroscienceThis project, developing an instrument for information processing and computing that enables cohesive study of the brain, involves the new concept of a 5-D brain processing platform while addressing the challenge of finding the best way to put together five dimensions to provide a complete picture of brain dynamics. This unified approach brings together fields of Computer Engineering, Computer Science, Electrical Engineering, and Bioengineering to create an instrument for precisely measuring and visualizing significant information and results across the five dimensions, three from spatial data, time, and an imaging modality that serves as the fifth dimension. Accomplishing this mission involves advanced designs, hardware-software integration mechanisms, and novel interfaces that bring competing, and sometimes diverging, technologies into a unified brain research platform. Combining a Multi-site Data Repository, Modality Integration and Computational, Visualization, and Operation Support Units, this new instrument is expected to bring:- New insights into brain structure, functional correlations and dynamics, both in its normal state and under specific pathological conditions,- Far improved mapping of patterns of brain activity,- Integration of multimodal technologies in order to augment their capabilities with new insights while consolidating high spatial resolution with high temporal resolution,- Database design and management augmented with mechanisms for fast user interaction and visualization to meet the challenge of managing complex spatio-temporal datasets, posing complex queries, and establishing effective methods for data representation and visualization, and- Resolution of those paradigms that confront heavy computational requirements and compatibility problems that arise from the use of different recording modalities and diverse software platforms.The project aims to collectively overcome the primary barriers in identifying the different factors that influence the functional organization of the brain and its underlying pathology. As an example, it delves in the epileptic seizure that can be mapped over time as it moves along specific fiber tracts that may enable better identification of specific areas of treatment and consequently protect functionally important parts of the brain during surgery that may lead to better and safer outcomes.Broader Impacts: Fostering an environment that supports cross disciplinary initiatives, joint collaboration and programs, the instrument establishes a research platform that enables academic institutions and hospitals to investigate multi-site collaborative studies in accordance to systematically administered standardize protocols to a database of common assessments and measures. The project extends the breadth and depth of multidisciplinary efforts including new paradigms and findings. Moreover, the project advances the education, research, and training of many students in a minority serving university.

“该奖项是根据2009年美国复苏和再投资法案（公法111-5）资助的。“提案编号：09- 59985 PI（s）：Malek的Alouadi; Armando的Barreto B.;盖拉尔，William; Jayakar，Prasanna; Rishe，Naphtali D.机构：佛罗里达国际大学名称： MRI-R2/Dev：神经科学中的信息科学和计算仪器本项目开发了一种用于信息处理和计算的仪器，可以对大脑进行连贯的研究，涉及5-D大脑处理平台的新概念，同时解决了寻找将5个维度组合在一起以提供完整的大脑动力学图片的最佳方法的挑战。这种统一的方法汇集了计算机工程，计算机科学，电气工程和生物工程领域，以创建一种仪器，用于精确测量和可视化五个维度的重要信息和结果，三个维度来自空间数据，时间和作为第五维的成像模式。完成这一使命需要先进的设计、软硬件集成机制和新颖的接口，这些接口将相互竞争、有时甚至是分歧的技术引入到一个统一的大脑研究平台中。结合多站点数据存储库、模态集成和计算、可视化和操作支持单元，这一新仪器预计将带来：- 在正常状态和特定病理条件下对大脑结构、功能相关性和动力学的新见解，-大大改进了大脑活动模式的映射，-整合多模式技术，以便通过新见解增强其能力，同时将高空间分辨率与高时间分辨率相结合，- 数据库设计和管理，增加了快速用户交互和可视化机制，以应对管理复杂时空数据集、提出复杂查询的挑战，并建立有效的数据表示和可视化方法，及─解决那些面临大量计算要求和兼容性问题的范例，这些问题是由于使用不同的记录方式和不同的软件平台而引起的。该项目旨在共同克服识别影响功能的不同因素的主要障碍。大脑的组织及其潜在的病理学。作为一个例子，它深入研究了癫痫发作，可以随着时间的推移，因为它沿着沿着特定的纤维束移动，可以更好地识别治疗的特定区域，从而在手术过程中保护大脑的功能重要部分，这可能会导致更好和更安全的结果。培养一个支持跨学科举措、联合协作和项目的环境，该工具建立了一个研究平台，使学术机构和医院能够根据共同评估和措施数据库的系统管理标准化协议，调查多地点合作研究。该项目扩展了多学科努力的广度和深度，包括新的范例和发现。此外，该项目还促进了少数民族大学的教育、研究和许多学生的培训。