Design Rules for Dynamic Macrocyclization

有了这个奖项，化学合成计划是支持教授杰弗里S。伊利诺伊大学香槟分校化学系的摩尔说。摩尔教授的研究工作围绕着功能大分子结构的合理设计。本计画将继续致力于发展动态炔复分解合成形状稳定大环化合物的有效方法。虽然通过动态共价化学制备形状持久的大环是一种既定的方法，但产物分布并不总是直观的，并且需要一套通用的单体设计标准。详细的结构-性质关系的研究将进行开发的单体身份的动态形成的大环的作用有更深的了解。从这些研究中，将开发一套设计规则，将概括的热力学控制下的大环化合物的有效制备的条件要求。具有潜在的新功能的新型亚芳基亚乙炔基大环的制备将是本研究的直接结果。该方法的成功开发将对战场传感器的开发产生影响，因为这些大环化合物对爆炸物及其前体高度敏感。此外，该项目将为研究生提供高级化学研究方面的优秀培训。科学推广活动，包括高中生，夏令营，科学俱乐部，并为电视台无偿科学咨询也是这个项目的组成部分。

With this award, the Chemical Synthesis Program is supporting the research of Professor Jeffrey S. Moore of the Department of Chemistry at the University of Illinois, Urbana-Champaign. Professor Moore's research efforts revolve around the rational design of functional macromolecular architectures. This project will continue work on the development of efficient methods for shape-persistent macrocycle synthesis by dynamic alkyne metathesis. While the preparation of shape-persistent macrocycles via dynamic covalent chemistry is an established process, product distribution is not always intuitive, and a general set of design criteria for monomers is needed. Detailed structure-property relationship studies will be undertaken to develop a deeper understanding of the role of the monomer identity on the dynamic formation of macrocycles. From these studies, a set of design rules will be developed that will generalize the conditional requirements for the efficient preparation of macrocycles under thermodynamic control. The preparation of novel arylene ethynylene macrocycles with potentially novel functionality will be a direct result of this study. Successful development of the methodology will have an impact on the development of sensors for battlegrounds, as these macrocycles are highly sensitive to explosives and their precursors. In addition, this project will provide excellent training in advanced chemistry research to graduate students. Scientific outreach activities involving high school students, summer camps, science clubs, and unpaid scientific consulting for TV stations are also integrative parts of this project.